X-Message-Number: 10767
Date: Thu, 12 Nov 1998 20:18:27 -0800 (PST)
From: Doug Skrecky <>
Subject: lycopene and vitamin E synergize to inhibit cancer growth

Biochemical and Biophysical Research Communications 250: 582-585 1998
"Lycopene in Association with Alpha-tocopherol Inhibits at Physiological
Concentrations Proliferation of Prostate Carcinoma Cells"


  The effect of lycopene alone or in association with other antioxidents
was studied on the growth of two different human prostate carcinoma cell
lines (the androgen insensitive DU-145 and PC-3). It was found that
lycopene alone was not a potent inhibitor of prostate carcinoma cell
proliferation. However, the simlutaneous addition of lycopene together with
alpha-tocopherol, at physiological concentrations (less than 1 microM and
50 microM, respectively), resulted in a strong inhibitory effect of
prostate carcinoma cell proliferation, which reached values close to 90%.
The effect of lycopene with alpha-tocopherol, was synergistic and was not
shared by beta-tocopherol, ascorbic acid and probucol.

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