X-Message-Number: 10848
Date: Fri, 27 Nov 1998 13:49:39 -0800 (PST)
From: Doug Skrecky <>
Subject: brain bank

2 Citations

<1>
Authors
  Palacin A.  Cardozo A.  Cardesa A.  Cruz-Sanchez FF.
Institution
  Department of Pathology, Hospital Clinico, University of Barcelona, Spain.
Title
  Brain banks and non nervous tissues. [Review] [45 refs]
Source
  Journal of Neural Transmission. Supplementum.  39:87-96, 1993.
Abstract
  Nervous system diseases may not be confined to neural tissue, but also affect
  other organs. These organs could be involved indirectly or could be
  simultaneously affected by the same pathological process. A
  brain bank (BB) should also guarantee the storage of
  specific organs primarily or secondary affected other than nervous system.
  Tissues from patients with primary nervous system diseases without or with
  unknown systemic involvement should also be stored. Samples stored will be
  identified and registered in a BB database for an accurate distribution and
  utilization of the material. To guarantee the best quality of the material
  stored, several techniques for the collection and preservation
  (cryopreservation, chemical fixation and microwave
  irradiation) and tissue management are described. [References: 45]

<2>
Authors
  Tourtellotte WW.  Rosario IP.  Conrad A.  Syndulko K.
Institution
  Neurology Service, VAMC W. Los Angeles, CA.
Title
  Human neuro-specimen banking 1961-1992. The National Neurological Research
  Specimen Bank (a donor program of pre- and post-mortem tissues and
  cerebrospinal fluid/blood; and a collection of cryopreserved human
  neurological specimens for neuroscientists). [Review] [15 refs]
Source
  Journal of Neural Transmission. Supplementum.  39:5-15, 1993.
Abstract
  The National Neurological Research Specimen Bank (The Bank) was established
  in 1961 to provide a vital service to neuroscientists. Our purpose is to
  support medical research which seeks the etiopathogenesis for devastating
  neurological disorders with no known cause, treatment or precise animal
  model. It serves as a bridge between the neurology clinician who diagnoses
  and cares for patients with incurable disease and the basic scientist who has
  need for specimens to find their etiopathogenesis. In the long run this
  service should advance neurologic diagnoses and serve as the basis for
  designing treatment. The Bank has grown to be the largest, most diverse
  neurological specimen bank of its kind in the world. It is a type of "tissue
  bank" where donor members "will" their central nervous system tissues to
  science. Then we collect, photograph, seal in air tight bags, quick freeze,
  cryogenically store and distribute on request the donated tissue to research
  scientists around the world. All tissue diagnoses are confirmed by clinical
  records and neuropathologic examination; further histology is conducted on
  request. In addition to brain and spinal cord tissues, the
  Bank has samples of other tissues. There are also samples of pre- and
  post-mortem CSF and sera from normal individuals and patients with various
  neurological disorders, especially serial specimens on multiple sclerosis
  patients and HIV-1 seropositive and at risk individuals. This paper outlines
  the global operations of our human brain bank, based on
  protocols developed and used by the authors. These operations include donor
  solicitation, tissue acquisition and documentation, tissue processing and
  storage, specimen dissemination to users, outcome assessment of banking,
  quality control, cost of our operation, table of organization and the future.
  [References: 15]

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