X-Message-Number: 11000 Date: Wed, 30 Dec 1998 23:58:16 -0800 From: Keith Rene Dugue <> Subject: Vitrification and Thermal stress To: Thomas Donaldson Thermal stress is caused by differential coefficients of expansion and/or temperature gradients. Assuming the brain can be cooled isothermally ,differing coefficients of expansion in the brain should still cause some thermal stress. How can this be eliminated or reduced? 21st Century Medicine's Synthetic Ice Blocker 21CM-X reduces Ice crystal formation. This will not eliminate the coefficient of expansion differential due to varying concentrations of water/glycerol in the different structures of the brain. I had the fortunate pleasure of speaking ,at some length, with Dr. Fahey about inhibiting ice formation. He seemed to think that they could squeeze some more performance out of their synthetic ice blocker technology. Of course ,he did not discuss any specifics of their proprietary work. I was very impressed to say the least ;however, I still don't understand how the coefficient of expansion differential will be eliminated or reduced to a level that will prevent brain cracking by even perfect vitrification. Keith R. Dugué NO SPAM -----BEGIN PGP PUBLIC KEY BLOCK----- Version: PGPfreeware 5.5.5 for non-commercial use <http://www.nai.com> Comment: !!! PLEASE STORE THIS FILE ENCRYPTED !!! mQGiBDRzwM0RBADWaGAFUCBGtlJv4CNvFaW7UlIkchbzZf/CiiXGJvFk0B9jTSEt OwsvzHL1/4SDEa40+M7rdYPtaxwFgY4OFGLKrNw/KTO6QfHmEZzOGzAjE5QfyvL9 wwmPhtQNogoOx+yau0GIy60Ia+/nuB2eDqBvWoB669wREQ8fAJrCBWaFPwCg/8uk wCRSQwDraa+s0pk/UOsn4ZsEAK9KGLmj7Orif1kvQmuPHlgmr7zCQN7GwPk5mWvd /jfQDne5xrqV0k9H1nVxIKCavE1ManAP8T4ntMnnC6t/STZd29vxmVwCbkHi9VcZ zOOsNcRGka2JrlfCyJxGSK3Ri9tIFztYvA831yc0DoxEetlHeeXdcdorTJ6NVfyj LJtoA/49kkpjfBHPJbWZlZsecoMKkqTW3pHjjCdqjRrHuliDW/udbmsRrI2Dssey RimzKaXh9vGTMw4B/wn2eSepEoUK4NbbryrTtER/yjTerfEJcwrtnNYrz4P4NTmw SK2bpl8IkDfm89v8nc1vTCRDp6i55zOBmMk0WzPQ2tRBMoGDwbQuS2VpdGggUmVu ZSBEdWd1ZSA8S2VpdGguZHVndWVAaW50ZXJuZXRtY2kuY29tPokASwQQEQIACwUC NHPAzQQLAwECAAoJENGRwPTtyPGdqKUAnjX0DMUy1tMRr5QXCpNJ5MMQyP5OAJsF edwdOX4CY1wCyTeipYdR+bBBFLkBDQQ0c8DREAQA+s/8VIndRqKas4sk8vakyZ+X V74bVxnKFPgy9AdN2gxkjLH5b6vlqIu4wGjC02jHtlgyysOBYCHcGSjv8T1N6N2U K8ogfGUmDi0NfKfNeV0HT4xNDAFfM7E29KORHB46s/m13gtxoXy5NNivaf08o4u2 v2Ee9gXOoKGamLQcJOcAAgIEAKZWY8kNQF9nm1xrs3vbHXmYOUzvKG8v3qYwWEn2 LtG+vBKp+2xyheDoDd5lPrUSzsw8Dx1Yw5Uk8CGuN8RR1iiRUygw3lIa7tsIxdbW 1zE3zPlTeMdmoVydu7IAujU/VwLtT5OJ7iusUsiLXyydfnyzawA/s/r21uzf5Nn+ FXwDiQA/AwUYNHPA0dGRwPTtyPGdEQKx8wCfRftqaKhhxhron/r8m9yJTrITXugA oImOMLOVWjuAiz+24T/NNtBPtCCX =JwJm -----END PGP PUBLIC KEY BLOCK----- Rate This Message: http://www.cryonet.org/cgi-bin/rate.cgi?msg=11000