X-Message-Number: 1154
Date: Wed, 19 Aug 92 20:44:23 -0700
Subject: Trans Time Newsletter #1

                         THE TRANS TIMES

                 Newsletter of TRANS TIME, INC.

10208 Pearmain Street, Oakland, CA 94603.            510-639-1955

Volume 1 Number 1                                     August 1992

                    THE BIRTH OF A NEWSLETTER

                      by Art Quaife, Ph.D.
                   President, TRANS TIME, INC.

TRANS TIME was incorporated on March 13, 1972. In the intervening
twenty years, we have communicated with persons interested in our
services through a variety of means. The media love us, so we have
had a steady stream of coverage on television and radio, and in
newspapers and magazines. We have also published articles in other
cryonics publications such as American Cryonics, ACS Notebook, The
Immortalist, Long Life Magazine, The Cryonicist, and Cryonics.

We will continue to use those channels. But over the years, many
people have become TRANS TIME stockholders, and others have become
customers for our Emergency Responsibility services. We need to
have our own publication, directed to the people with whom we do
business. Here is the first issue of our newsletter, dedicated to
meeting that need.


In this newsletter, we will attempt to cover improvement of our
capabilities, developments related to making suspension arrange-
ments, and equipment acquisitions. We will also cover important re-
search developments and general cryonics news. 

                      TWENTIETH ANNIVERSARY

TRANS TIME was formed twenty years ago by the most active members
of the the American Cryonics Society. We decided that it was time
to go beyond talking about what a great idea cryonics was, and form
a company to provide the service for ourselves and others. We real-
ized that the best way to raise money for equipment and supplies
was through forming a stock corporation. As the only for-profit
cryonics service provider in the world, we continue to offer
cryonicists an opportunity to support the growth of cryonics while
simultaneously earning a return on the growth of their stock

Eight persons incorporated TRANS TIME. One was Art Quaife, who has
been the President ever since. Another was Jerry White, who has
been on the Board most of the time since, and also served twelve
years as President of ACS. A third was Linda Chamberlain, who with
her husband Fred also formed the Alcor (non-profit) and Manrise
(for-profit) organizations. In 1977, we bought out Manrise and
merged it into TRANS TIME.

All of the original incorporators remain involved in cryonics, to
a greater or lesser extent, except Grace Talbott, who was an M.D in
her seventies when TRANS TIME was formed. She died three years
later, without having made any suspension arrangements, and was not

At our Annual Meeting of Shareholders on April 26, we ate birthday
cake reading "Trans 20 years Time, Going on omega" and toasted that
thought liberally with champagne.


[ Text deleted because it duplicates the content of message #1114
  "How to Freeze a Human", which you can retrieve by sending
  email to me with the Subject line "CRYOMSG 1114". - KQB ]


TRANS TIME has a close working relationship with BioTime, Inc. Drs.
Paul Segall, Hal Sternberg, and Harold Waitz, BioTime's principal
researchers, have a long history of affiliation with TRANS TIME.
Hal Sternberg is currently our Vice-President, and BioTime
Secretary Judy Segall is also TRANS TIME's Secretary.

BioTime has raised about $5,000,000 to develop further a blood
substitute that may have a variety of surgical applications. We use
their blood substitute in the cryonic suspension of our patients.
We have the right to use any of their products for cryonics
purposes. And we own shares of their stock currently trading on the
NASDAQ for more than $300,000.

All of which leads to the following press release:

                      BRING 'EM BACK ALIVE!

Berkeley, California, May 29 1992. "BioTime Inc. has, for the first
time, successfully revived a baboon following a procedure in which
the animal's deep body temperature was lowered to near-freezing and
its blood was replaced with BioTime's patent-pending blood-
substitute solution.

"The animal was anesthetized, immersed in ice and cooled to below
2 degrees Celsius, using the BioTime solution with cardiopulmonary
bypass procedures. After being bloodless and below 10 degrees
Centigrade for 55 minutes, the animal was rewarmed and revived. The
baboon is presently under study by BioTime scientists to determine
any long-term physical effects.

"The company intends to conduct further experiments on primates,
using its blood-substitute solutions."

The baboon was initially weak in its hindquarters, but has experi-
enced normal recovery. At this writing it is alert and very active,
showing no signs of brain damage.

The BioTime experimenters were ably assisted by the expert staff of
a private research laboratory, whose personnel also assist TRANS
TIME in cryonic suspensions.

The research was broadcast nationwide on CNN News on July 28, 1992.
Over the past five years, we have had a number of similar successes
with dogs, including recovery after four and one half hours of cold
washout. Now we are scaling up one step closer to humans. The
research team is now attempting to extend the bloodless-cold time
to three hours.

The earlier dog research is reported in detail in "Ultraprofound
hypothermia with complete blood substitution in a canine model,"
Julian Bailes et al., Journal of Neurosurgery 74:781-788, 1991.

                         OTHER RESEARCH

Here we include an abstract describing some of their other recent
research. This abstract was published in the Federation of American
Societies for Experimental Biology Journal 6:4, February 26, 1992.

P.E. Segall and H.D. Waitz. BioTime, Inc., Berkeley, CA 94710.

Core-cooling of organ donors can increase the quality of organs for
transplantation. The hamster (Mesocricetus auratus), provides a
convenient and inexpensive model to develop blood-substitutes for
ultraprofound hypothermia. Five hamsters were anesthetized with
ketamine, cooled to 12-14 degrees C, and their right carotid arter-
ies cannulated. They were then chilled to 4 degrees C and their
right jugular veins punctured to allow venous effluent outflow.
Using a modified BioTime Z+ solution (an ice-cold synthetic
buffered aqueous perfusate containing electrolytes, sugars, and
Dextran 40), they were blood-substituted until their hematocrits
were approximately 10%, and cardiac arrest had occurred. The
hamsters were then buried in crushed ice for 3 hours. Afterward,
they were perfused with the BioTime Z+ solution (2 hamsters), or a
second modified Z+ solution (3 hamsters), warmed slightly, and then
perfused with whole hamster blood. All animals revived until they
could respond to stimuli.

In additional studies, a series of 5 chilled hamsters were blood-
substituted with modified Z+ solution, and then perfused with
BioTime Z~ solutions (similar to Z+ solution, but with cryoprotec-
tive agents added). The hamsters were then partially-frozen
overnight (15-18 hours) in a saline slush until their deep body
temperatures reached minimums of -2.7 to -3.5 degrees C, thawed in
a commercial microwave oven, perfused with Z+ solution, and then
warmed and transfused with donor whole blood. In each case
heartbeat was restored. 

Rate This Message: http://www.cryonet.org/cgi-bin/rate.cgi?msg=1154