X-Message-Number: 11816
Date: Mon, 24 May 1999 18:25:54 -0700 (PDT)
From: Doug Skrecky <>
Subject: neuroprotection with coenzyme q10

  Matthews RT.  Yang L.  Browne S.  Baik M.  Beal MF.
  Neurochemistry Laboratory, Neurology Service, Massachusetts General Hospital
  and Harvard Medical School, Boston, MA 02114, USA.
  Coenzyme Q10 administration increases brain mitochondrial concentrations and
  exerts neuroprotective effects.
  Proceedings of the National Academy of Sciences of the United States of
  America.  95(15):8892-7, 1998 Jul 21.
  Coenzyme Q10 is an essential cofactor of the electron transport chain as well
  as a potent free radical scavenger in lipid and mitochondrial membranes.
  Feeding with coenzyme Q10 increased cerebral cortex concentrations in 12- and
  24-month-old rats. In 12-month-old rats administration of coenzyme Q10
  resulted in significant increases in cerebral cortex mitochondrial
  concentrations of coenzyme Q10. Oral administration of coenzyme Q10 markedly
  attenuated striatal lesions produced by systemic administration of
  3-nitropropionic acid and significantly increased life span in a transgenic
  mouse model of familial amyotrophic lateral sclerosis. These results show
  that oral administration of coenzyme Q10 increases both brain and brain
  mitochondrial concentrations. They provide further evidence that coenzyme Q10
  can exert neuroprotective effects that
  might be useful in the treatment of neurodegenerative diseases.

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