X-Message-Number: 11884
Date: Fri, 4 Jun 1999 01:19:34 -0700 (PDT)
From: Doug Skrecky <>
Subject: deprenyl increases mortality

  Gallagher IM.  Clow A.  Glover V.
  Department of Paediatrics, Queen Charlotte's & Chelsea Hospital, London,
  United Kingdom.
  Long-term administration of
  (-)-deprenyl increases mortality in male Wistar rats.
  Journal of Neural Transmission. Supplementum.  52:315-20, 1998.
  Long-term administration of the monoamine
  oxidase inhibitor (-)-deprenyl (0.5 mg/Kg) for up to 20
  months significantly increased mortality in the male Wistar rat, whereas the
  dopamine agonist pergolide (0.4 mg/Kg) and the antioxidant
  diethyldithiocarbamate (400 mg/Kg) had no significant effect on mortality.
  The increased mortality was not related to dietary intake or body weight of
  the rats. This is of interest in the light of recent evidence that
  (-)-deprenyl increases mortality in humans.

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