X-Message-Number: 11896
Date: Sat, 5 Jun 1999 14:00:45 -0700 (PDT)
From: Doug Skrecky <>
Subject: preservation of brain with aspirin

  Pakhotin PI.  Pavlik LL.  Pakhotina ID.  Andreev AA.
  Ecological Acoustics Group, Biocrystalophysics Group, Russian Academy of
  Sciences, Pushchino, Moscow District.
  [Long-term morphofunctional preservation of
  guinea pig hippocampal slices following short-term treatment with
  cyclooxygenase inhibitors]. [Russian]
  Morfologiia.  114(5):30-4, 1998.
  Hippocampal slices treated with cyclooxygenase inhibitor indomethacin for
  three min during the sectioning (45 min) or aspirin (0.5 min) in long term
  (up to 5 days) preservation in periodic nocturnal hypothermia were studied
  morphofunctionally using light microscopy and
  electrophysiological registration of induced population responses of area CAI
  to stimulation of Schaffers collaterals. Structural disorders were revealed
  in control slices as early as the third hour of incubation and they were
  destroyed following the first hypothermal challenge (24 hrs following
  preparation). The structure in slices treated with blockers remained more
  stable as compared to control ones and the activity was registered until d 3
  (aspirin) and 5 (indomethacin). Morphological changes were not immediately,
  followed by electric activity decline. On the whole it may be suggested that
  essential viability increase occurred due to destructive processes inhibition
  mediated by short living cyclooxygenase metabolites.

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