X-Message-Number: 11950
Date: Sat, 12 Jun 1999 09:16:04 -0700 (PDT)
From: Doug Skrecky <>
Subject: PBN increases lifespan in mice

(Dr Proctor holds the patents on PBN)

From:  (Peter H. Proctor)
Newsgroups: sci.life-extension,misc.health.alternative

         Here is a favorite PBN paper from the National Institute on Aging.   
Note that it is effective from drinking water.    BTW,  24 months is fairly 
elderly for a mouse.

Peter H. Proctor, PhD, MD

Also see more on PBN at http://www.nitrone.com

Biosci Biotechnol Biochem 1998 Apr;62(4):792-4 

A spin trap, N-tert-butyl-alpha-phenylnitrone extends the life span of mice.

Saito K, Yoshioka H, Cutler RG
 Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD 
21224, USA. 

 To characterize the pharmacological effects of N-tert-butyl-alpha-phenyl
nitrone (PBN) on life span, we administered PBN in drinking water to 24.5
-month-old mice, and the survivors were counted. Their water consumption 
and body weights were measured as biological markers. PBN-treated animals
 as compared with control animals had prolonged mean and maximum life spans. 
Their water consumption decreased but no significant change was found in their 
body weights, indicating that the metabolism was improved. Results showed that 
PBN indeed affects physiological functions and extends life span. We propose 
that nitric oxide release from PBN may be involved in altering the aging 

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