X-Message-Number: 11962
Date: Tue, 15 Jun 1999 03:17:01 -0700 (PDT)
From: Doug Skrecky <>
Subject: scavenging effect of Chinonin

Authors
  Zhao B.  Shen J.  Li M.  Li M.  Wan Q.  Xin W.
Institution
  Institute of Biophysics, Academia Sinica, Beijing, China.
Title
  Scavenging effect of Chinonin on NO and
  oxygen free radicals and its protective effect on the
  myocardium from the injury of ischemia-reperfusion.
Source
  Biochimica et Biophysica Acta.  1315(2):131-7, 1996 Mar 1.
Abstract
  The scavenging effect of Chinonin on NO and
  oxygen free radicals and its protective effect on myocardium
  from the ischemia-reperfusion injury was studied with electron spin resonance
  (ESR) and chemiluminescence techniques. Chinonin can
  effectively inhibit the oxidative activity of ONOO-, (the
  IC50 = 7 x 10 (-5) mmol/L) and scavenge oxygen free radicals generated from
  the reaction of xanthine and xanthine oxidase (the IC50 = 2/5 x 10(-4)
  mmol/l). It is difficult to find another antioxidant which can scavenge so
  effectively both ONOO- and oxygen free radicals
  simultaneously. In the system of ischemia-reperfusion injury of myocardium,
  Chinonin can, in parallel, scavenge the NO and oxygen free radicals generated
  from the ischemia-reperfused myocardium, and decrease the activities of
  lactate dehydrogenase (LDH) and creatine kinase (CK) in the coronary artery
  effluent of ischemia-reperfused heart and therefore protect the heart from
  ischemia-reperfusion injury. The protective effect of 0.1
  mmol/l Chinonin is similar to that of 1500 U/ml SOD and catalase.

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