X-Message-Number: 11962 Date: Tue, 15 Jun 1999 03:17:01 -0700 (PDT) From: Doug Skrecky <> Subject: scavenging effect of Chinonin Authors Zhao B. Shen J. Li M. Li M. Wan Q. Xin W. Institution Institute of Biophysics, Academia Sinica, Beijing, China. Title Scavenging effect of Chinonin on NO and oxygen free radicals and its protective effect on the myocardium from the injury of ischemia-reperfusion. Source Biochimica et Biophysica Acta. 1315(2):131-7, 1996 Mar 1. Abstract The scavenging effect of Chinonin on NO and oxygen free radicals and its protective effect on myocardium from the ischemia-reperfusion injury was studied with electron spin resonance (ESR) and chemiluminescence techniques. Chinonin can effectively inhibit the oxidative activity of ONOO-, (the IC50 = 7 x 10 (-5) mmol/L) and scavenge oxygen free radicals generated from the reaction of xanthine and xanthine oxidase (the IC50 = 2/5 x 10(-4) mmol/l). It is difficult to find another antioxidant which can scavenge so effectively both ONOO- and oxygen free radicals simultaneously. In the system of ischemia-reperfusion injury of myocardium, Chinonin can, in parallel, scavenge the NO and oxygen free radicals generated from the ischemia-reperfused myocardium, and decrease the activities of lactate dehydrogenase (LDH) and creatine kinase (CK) in the coronary artery effluent of ischemia-reperfused heart and therefore protect the heart from ischemia-reperfusion injury. The protective effect of 0.1 mmol/l Chinonin is similar to that of 1500 U/ml SOD and catalase. Rate This Message: http://www.cryonet.org/cgi-bin/rate.cgi?msg=11962