X-Message-Number: 12001
Date: Thu, 24 Jun 1999 20:41:54 -0700 (PDT)
From: Doug Skrecky <>
Subject: pycnogenol and senescence accelerated mice

  Liu FJ.  Zhang YX.  Lau BH.
  Department of Microbiology and Molecular Genetics, School of Medicine, Loma
  Linda University, California 92350, USA.
  Pycnogenol enhances immune and haemopoietic functions in
  senescence-accelerated mice.
  Cellular & Molecular Life Sciences.  54(10):1168-72, 1998 Oct.
  Pycnogenol (procyanidin extracted from Pinus maritima) has
  been shown to be a potent free radical scavenger and an antioxidant
  phytochemical. The effects of pycnogenol on immune and
  haemopoietic dysfunction in senescence-accelerated mice (SAM), as a murine
  model of accelerated ageing, were determined. SAMP8, a strain of senile-prone
  mice, exhibit learning and memory deficits, immunodeficiency and dysfunction
  of the haemopoietic system. Oral feeding with pycnogenol for
  2 months significantly improved their T- and B-cell function.
  Pycnogenol also augmented the proliferative capacity of
  haemopoietic progenitors of bone marrow in SAMP8. These data suggest that
  pycnogenol may be useful for either retardation or
  restoration of parameters associated with ageing.

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