X-Message-Number: 12073
Date: Mon, 5 Jul 1999 18:59:40 -0700 (PDT)
From: Doug Skrecky <>
Subject: antioxidants in thyme

  Haraguchi H.  Saito T.  Ishikawa H.  Date H.  Kataoka S.  Tamura Y.  Mizutani
  Faculty of Engineering, Fukuyama University, Japan.
  Antiperoxidative components in Thymus
  Planta Medica.  62(3):217-21, 1996 Jun.
  A biphenyl compound,
  3,4,3',4'-tetrahydroxy-5,5'-diisopropyl-2,2'-dimethylbiphenyl (1), and a
  flavonoid, eriodicytol (2), were isolated as antioxidative
  components from the leaves of Thymus vulgaris by
  bioassay-directed fractionation. These compounds inhibited superoxide anion
  production in the xanthine/xanthine oxidase system. Mitochondrial and
  microsomal lipid peroxidation induced by Fe(III)-ADP/NADH or
  Fe(III)-ADP/NADPH were also inhibited by these compounds. Compound 1 is an
  extremely potent antioxidant; complete inhibition was observed at 1 microM
  against both microsomal and mitochondrial peroxidation. Furthermore, compound
  1 protected red cells against oxidative hemolysis. These phenolic compounds
  were shown to be effective to protect biological systems against various
  oxidative stresses.

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