X-Message-Number: 12399
Date: Sat, 11 Sep 1999 10:02:28 -0700 (PDT)
From: Doug Skrecky <>
Subject: bilobalide may be the main active ingrediant in ginkgo

  Klein J.  Chatterjee SS.  Loffelholz K.
  Department of Pharmacology, University of Mainz, Germany.
  Phospholipid breakdown and
  choline release under hypoxic conditions: inhibition by
  bilobalide, a constituent of Ginkgo biloba.
  Brain Research.  755(2):347-50, 1997 May 2.
  A marked increase of choline release from rat hippocampal
  slices was observed when the slices were superfused with oxygen-free buffer,
  indicating hypoxia-induced hydrolysis of choline-containing
  phospholipids. This increase of choline
  release was suppressed by bilobalide, an ingredient of Ginkgo biloba, but not
  by a mixture of ginkgolides. The EC50 value for bilobalide was 0.38 microM.
  In ex vivo experiments, bilobalide also inhibited hypoxia-induced
  choline release when given p.o. in doses of 2-20 mg/kg 1 h
  prior to slice preparation. The half-maximum effect was observed with 6 mg/kg
  bilobalide. A similar effect was noted after p.o. administration of 200 mg/kg
  EGb 761, a ginkgo extract containing approximately 3% of bilobalide. We
  conclude that ginkgo extracts can suppress hypoxia-induced membrane
  breakdown in the brain, and that bilobalide is the active
  constituent for this effect.

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