X-Message-Number: 12416
Date: Tue, 14 Sep 1999 02:45:06 +0000
From: Kennita Watson <>
Subject: Heparin preloading?

What I get from this is that it may be useful for gravely ill 
cryonicists to be administered enoxaparin premortem to reduce 
clotting that could interfere with perfusion.

Is this ever done?  If not, is it because I'm missing something
or because nobody ever thought of it?

Thanks,
Kennita

WESTPORT, Sep 09 (Reuters Health) - Prophylactic therapy with the
low-molecular-weight heparin,
enoxaparin, safely reduces rates of venous thromboembolism in acute
medical patients, according to a
study in the September 9th issue of the New England Journal of Medicine.

In the double-blind placebo-controlled study, Dr. Meyer Samama of the
Hotel Dieu in Paris, France,
and colleagues randomly assigned 1102 hospitalized patients into one of
three treatment groups: 40
mg of enoxaparin, 20 mg of enoxaparin or placebo. The patients, who
received subcutaneous injections
once daily for six to 14 days, were over the age of 40 and had either
congestive heart failure, acute
respiratory failure or some other condition that put them at risk for
developing venous
thromboembolism

From hospital days 1 to 14, venous thromboembolism occurred in only 5.5%
of the group that
received 40 mg enoxaparin, significantly less than the 15% in the 20-mg
group and 14.9% in the
placebo group. The difference was maintained in the 40-mg group at a
3-month follow-up. No
differences in adverse events were observed among the three groups.

"[D]aily injections of 40 mg of enoxaparin," the researchers conclude,
"significantly reduced the
incidence of venous thromboembolism in acutely ill medical patients
during hospitalization without
increasing the risk of major hemorrhage."
-- 
Kennita Watson           |   Late to bed, early to rise,
       |      work like hell, and advertise."  
http://i.am/Kennita      |               -- Werner von Braun

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