X-Message-Number: 13091
Date: Sat, 15 Jan 2000 16:38:14 -0800
From: Jeff Davis <>
Subject: penetrating the blood-brain barrier


Occasionally, when the subject of cryoprotectant absorbtion by brain tissue
comes up, the Blood-Brain Barrier is mentioned as an impediment.  The
following article from Eurekalert has some promising news re the BBB problem.

Oregon Health Sciences University Researchers track
    long-term results of chemotherapy assisted by
    blood-brain barrier disruption 

The article mentions that

>More than 15 years ago, OHSU neurosurgeon Edward A. Neuwelt, M.D.,
pioneered a
>    unique method for outwitting the blood-brain barrier. Neuwelt found
the introduction
>    of a concentrated sugar solution caused a temporary disruption of the
barrier allowing
>    for the passage of chemotherapy drugs.

Which I find interesting because, as I recall, some animals use elevated
sugar levels as a kind natural "antifreeze"(cryoprotectant)  when exposed
to extreme cold in their natural environment.

And while I'm on the subject, not that long ago there was this, again from

University of Maryland Medical Center 

    UM researchers discover 'key' to blood-brain barrier 

    Findings Could Lead to New Treatments for Brain Disorders 

    Researchers at the University of Maryland School of Medicine in
Baltimore have
    identified a receptor in the human brain that regulates the interface
between the
    bloodstream and the brain, which is known as the blood-brain barrier.

The full text of the announcements can be found at Eurekalert, which can be
found at:


			Best, Jeff Davis

	   "Everything's hard till you know how to do it."
					Ray Charles				

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