X-Message-Number: 13125 Date: Fri, 21 Jan 2000 11:59:06 -0800 (PST) From: Doug Skrecky <> Subject: reversible fixation with flavonoids? Authors Mantle D. Falkous G. Perry EK. Institution Medicinal Plant Research Centre, University of Newcastle-upon-Tyne, UK. Title Effect of flavonoids on protease activities in human skeletal muscle tissue in vitro. Source Clinica Chimica Acta. 285(1-2):13-20, 1999 Jul. Abstract The effect of a representative range of flavonoid compounds on the activities of a range of proteolytic enzyme types in human skeletal muscle tissue was determined in vitro. All of the proteases showed some degree of inhibition by all of the flavonoid compounds investigated, with IC50 values (concentration of flavonoid required to inhibit initial activity of muscle proteases by 50%) for various enzyme/flavonoid combinations ranging from approx. 50 micromol/l to 2 mmol/l. These data demonstrate that in addition to their well described antioxidant characteristics, flavonoids also possess novel antiproteolytic inhibitory activity in vitro, which may in part explain some of the beneficial effects of these plant derived compounds in vivo. Additional quote: "the most effective proteolytic inhibitors were myricetin and morin" ... "effect of flavonoid compounds on protease activities in human brain and liver tissues gave broadly similar IC50 values" Rate This Message: http://www.cryonet.org/cgi-bin/rate.cgi?msg=13125