X-Message-Number: 13125
Date: Fri, 21 Jan 2000 11:59:06 -0800 (PST)
From: Doug Skrecky <>
Subject: reversible fixation with flavonoids?

  Mantle D.  Falkous G.  Perry EK.
  Medicinal Plant Research Centre, University of Newcastle-upon-Tyne, UK.
  Effect of flavonoids on protease activities
  in human skeletal muscle tissue in vitro.
  Clinica Chimica Acta.  285(1-2):13-20, 1999 Jul.
  The effect of a representative range of flavonoid compounds
  on the activities of a range of proteolytic enzyme types in human skeletal
  muscle tissue was determined in vitro. All of the proteases showed some
  degree of inhibition by all of the flavonoid compounds investigated, with
  IC50 values (concentration of flavonoid required to inhibit initial activity
  of muscle proteases by 50%) for various enzyme/flavonoid combinations ranging
  from approx. 50 micromol/l to 2 mmol/l. These data demonstrate that in
  addition to their well described antioxidant characteristics,
  flavonoids also possess novel antiproteolytic inhibitory
  activity in vitro, which may in part explain some of the beneficial
  effects of these plant derived compounds in vivo.

  Additional quote:

    "the most effective proteolytic inhibitors were myricetin and morin"
    "effect of flavonoid compounds on protease activities in human brain
  and liver tissues gave broadly similar IC50 values"

Rate This Message: http://www.cryonet.org/cgi-bin/rate.cgi?msg=13125