X-Message-Number: 13256
Date: Mon, 14 Feb 2000 17:22:11 -0700
From: Linda Chamberlain <>
Subject: Fourth Alcor Conference on Life Extension Technologies

Fourth Alcor Conference on Life Extension Technologies


June 17-18, 2000:  Mark Your Calendars Today!

Register Early and Save!
Register before March 1, 2000 to be sure of 
On-site lodging.  See details below.

The world is changing rapidly.  Only a few years ago, 
most people considered  mammalian cloning to be no 
more than science fiction.   Repeated successes in this 
area,  however, have made it a reality today.  More 
importantly, medical technologies like cloning and the 
use of embryonic stem cells to regenerate tissues, 
promise to make it possible to reverse all the major 
degenerative diseases within our own lifetimes.  
Even aging itself is under very heavy attack by today s 
biological and medical technologies.  

The Fourth Alcor Conference on Life Extension 
Technologies is a meeting of scientists, technologists and 
individuals who are working in fields leading toward the 
expansion of human health and longevity.  

Conference Sponsors:

Primary Sponsor: Alcor Life Extension Foundation

Co-Sponsor: Foresight Institute

Academic Sponsors:

American Academy of Anti-Aging Medicine

Medicina Interna Gerontogeriatria y Medicina Anti-
Envejecimiento, A.C.

Corporate Sponsors: 

Principal Sponsor:  Future Electronics 

Event Sponsors: 
James Halperin Foundation, Voxtran, Inc.

General Sponsor:  BioTransport, Inc.

Supporting Sponsor:  NanoTechnology Magazine

Basic Sponsor:  Life Extension Vitamin Supplies

Conference Patrons: 

Stephen Bridge
Fred Chamberlain 
Linda Chamberlain 
David Greenstein, OD
Ravin Jain, MD
Eric King
Philip Longpre
Gary Meade, Esq.
Irene Olberz
Charles Reddeck
Michael Riskin, CPA, PhD
Corrine Serra
Austin Tupler 


Glenna Burmer, MD, PhD

Title:  Identifying Aging Genes by Using DNA 

DNA Microarrays or "gene chips" are one of the most 
powerful methods in biotechnology for simultaneously 
analyzing the expression of thousands of human genes in 
human diseases. LifeSpan is building a database of gene 
expression in human aging and the diseases of aging 
using microarrays and methods of high throughput 
localization to find candidates that may be the drug 
targets for the treatment of aging diseases. Data will be 
presented on genes that are up-regulated or down-
regulated in aging, those that are drug targets or potential 
diagnostic markers, and those for which a function is not 
yet known, but are clearly aging-associated. The high 
throughput nature of this type of technology is changing 
the way discoveries are being made in both the field of 
aging as well as medicine in general.

Fred Chamberlain, BBE

Title: Bioimpedance

Bioimpedance, a biological electrical characteristic 
where tissues with intact cell membranes behave very 
differently from tissues that have undergone cell 
membrane breakdown, is sustained for extended periods 
after cessation of heartbeat and breathing.  Automated 
means of comparatively evaluating cryostasis protocols, 
as well as means for monitoring and comparing specific 
cryotransport operations, will be reported in the context 
of early experimentation and (if circumstances have 

permitted) actual cryotransports.

Eric K. Drexler, PhD

Title:The Conservative Treatment of Transient Inviability 
or Your computer crashed -- shall I throw it out?

Emerging nanotechnologies will lead to cellular-scale 
robotic surgical devices able to sense and repair tissues 
with molecular precision. Those of us who stay intact 
until this technology arrives could achieve and keep good 
health indefinitely. Traditional medicine discards patients 
if their vital processes are interrupted for more than a few 
minutes. In light of the prospects for future repair, this 
treatment - physical destruction of potentially healthy 
human beings -- seems regrettable. Physicians wishing to 
save lives should instead recommend treatments that 
keep patients intact for restoration using the next 
generation of medical technologies.

Gregory M. Fahy, PhD

Title: Cryobiological Research at 21st Century Medicine

21st Century Medicine is probing a broad range of 
problems in cryobiology. A central aspect is our attempt 
to demonstrate successful cryopreservation of 
mammalian organs, particularly the kidney. Construction 
of perfusion equipment, new surgical approaches, our 
new surgical staff, and initial results of perfusion with 
novel, low-toxicity vitrification solutions will be 

James J. Hughes, PhD 

Title:  Our Evolving Definitions of Death: Looking 

The definition of death varies cross-culturally. "Death" 
has also changed radically in the West in the last thirty 
years. The shift from circulation and respiration-based 
definitions of death to "whole brain death" has left us in 
an unstable compromise. Just as mechanical heart-lung 
aids forced us from body to brain, advances in 
remediation of brain injuries will force us to 
grapple with questions about the integrity and continuity 
of personhood. Cryonics will be a part of a group of 
therapeutic modalities that will force a new personal 
identity-based concept of rights. The question may shift 
from "Live or dead?" to "What can we do with/who 
controls various kinds of bodies, with various degrees of 
consent or prior expressed will on the part of the 
occupant?" I will discuss some political and legal 
scenarios. One possible outcome might be that the re-
animated cryonaut would be a legally and 
phenomenologically different person than the person who 
was frozen.

Ralph Merkle, PhD

Title:   Nanomedicine and Cryostasis

Human beings are made from molecules, and how those 
molecules are arranged makes the difference between 
good health and bad, between youth and old age, and 
between life and death. Most medical problems involve 
damage at the molecular and cellular level. Today's 
medical tools are very limited in their ability to deal with 
such damage. In the future, with nanotechnology, we 
should be able to arrange and rearrange molecular 
structures in most of the ways permitted by physical law. 
The medical applications of such an ability will be 
remarkable. We should be able to heal and cure under 
conditions that today would be considered completely 
hopeless. We should even be able to reverse freezing 

injury, giving us the ability to restore to health people 
who have been frozen using today's methods.

Richard Morales, MD

Title: Setting Your Internal Clock Circadian rhythms are 
well known scientific phenomenon.  Recently, we 
have learned how to reset our internal clocks with diet, 
exercise, sleep and hormonal manipulation.  Dr. Morales 
will discuss some of the breakthroughs in this area and 
their application to anti-aging medicine.

Robert R. Newport, MD

Title: Fear of Death Intereferes with Rational Processes

In this brief presentation we will try to lay the foundation 
for understanding how the 'fear of death' arises and how 
it interferes with an individuals rational process, 
especially in relation to  acting to preserve, extend and 
possibly, via cryonic suspension, return to, life. We will 
draw on the work of Stanislaw Groff MD and my own 
personal experience from 30 years of working with 
depressed and anxious patients in a private practice of 
psychiatry. Due to the brevity of the session, audience 
participation will be held during the lunch break. We will 
also review current research on the effects of stress on 
early brain development.  

Tomas A. Prolla, PhD

Title: Gene Expression Profile of the Aging Process 

The gene expression profile of the aging process was 
analyzed in skeletal muscle of mice. Use of high-density 
oligonucleotide arrays representing 6347 genes revealed 
that aging resulted in a differential gene expression 
pattern indicative of a marked stress response and lower 
expression of metabolic and biosynthetic genes. Most 
alterations were either ompletely or partially prevented 
by caloric restriction, the only intervention known to 
retard aging in mammals. Transcriptional patterns of 
calorie-restricted animals suggest that caloric restriction 
retards the aging process by causing a metabolic shift 
toward increased protein turnover and decreased 
macromolecular damage. Gene expression profiling of 
the aging process provides a new tool to test aging 

Gregory Stock, PhD

Title:  Who's afraid of freezer burn?

Long before biological reconstruction of a frozen body 
(or brain) could be feasible, technology would have to 
advance sufficiently for uploading to occur.  Moreover, 
the technological developments needed even for 
uploading are sufficiently powerful to dramatically 
transform the world in a way that would make biology a 
far less interesting substrate for life than silicon and its 
progeny. The incentives for a biological rather than a 
technological awakening from a cryonic state are 
unlikely ever to exist, so cryonists -- if they are someday 
revived -- are almost certainly bidding adieu to corporeal 

Natasha Vita-More   

An after dinner presentation by Natasha Vita-More on 
her current book project followed by a panel discussion. 

A Talent for Living: Cracking the Myths of Mortality.  
Many have written about the technologies of extending 
life but not why we would want to live longer. There is 
an art to living - how we maintain our well being and 
how we bring aesthetics into our lives.  We can approach 

life merely as a series of events or as a creative and 
challenging exploration. The panel will examine the 
cultural myths preventing mainstream acceptance of 
extreme life extension and discuss how to crack them. 

Michael West, PhD

Title: Human Therapeutic Cloning

Many technologies have been developed and refined in 
the past few years that set the stage for human 
therapeutic cloning as a potentially limitless source of 
cells for tissue engineering and transplantation medicine. 
These technologies include the identification and 
isolation of pluripotent stem cells that are capable of 
generating all of the cell types in the body, genetic and 
cell engineering techniques enabling the designee of 
custom tissues and organs, and advanced in somatic cell 
nuclear transfer to clone ungulates confluence of these 
technologies will lead to means for developing 
tissue therapies that will overcome the present difficulties 
related to immune compatibility and graft rejection, and 
thus the requirements for use of immunosuppressive 
drugs and/or immunomodulatory protocols.

Brian Wowk, PhD 

Title: Molecular Control of Ice Formation

Antifreeze proteins and ice nucleating proteins found in 
nature are able to respectively prevent or catalyze the 
formation of ice while present in very small quantities. It 
has recently been demonstrated that synthetic molecules 
are able to perform similar functions. The availability of 
inexpensive synthetic molecules for blocking ice 
formation opens new frontiers for control of ice in 
industry and agriculture, and for eliminating ice in 
cryopreservation applications.

Asilomar Conference Center
Monterey Peninsula, Northern California

Staying on-site at Asilomar is a memorable experience.  
Once you arrive, there is no driving and no hurry.  Three 
excellent cafeteria-style meals are included each day.  
Maid service, beach and swimming pool.  Everything is 
close and convenient.  Prices dictated by ccommodations 
selected.  Non-conference guest reservations accepted.  
Attendees who want to bring their families find it to be a 
wonderful vacation for non-attendees.  Attendees and 
their families can come early or stay late to enjoy the 
general Monterey Peninsula and take advantage of 
Asilomar's economical food and lodging package.  But 
reservations must be made by March 1 in order to be sure 
that you will be able to obtain on-site lodging.

Don't be disappointed by trying to make reservations at 
the last minute only to learn that they no longer have 
accommodations that will fit your needs - or worse, that 
they are sold out completely.   Save money, as well, by 
registering for the Conference in advance. Take dvantage 
of the early registration rates! Register on-line today. 

Lodging and meals package at Asilomar is available at 

www.alcor.org, by calling Asilomar at 831-372-8016, or 
an information package can be requested by calling 
Alcor Life Extension Foundation toll-free 
at 877-462-5267. 

Register Early and Save!

Register before March 1, 2000 
to be sure of onsite lodging

Early Registration:    
$250/person if registered before March 1, 2000
(on-site lodging available - it fills fast - don't wait)

General Registration    $300/person if registered
before June 1, 2000
At The Door (after June 1, 2000)  $400/person

The following discounts are available: 
30% Discount off any fee above for Alcor Life Members 	
10% Discount off any fee above for the following: 

Alcor Regular Members
Members of Extropy Institute
Members of Foresight Institute

Register Early and Save!

Call for registration package:

Alcor Life Extension Foundation, 
FAX: 480-922-9027 
VOICE: 480-905-1906

www.alcor.org (Register On-line)

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