X-Message-Number: 13276 Date: Sun, 20 Feb 2000 23:53:25 -0500 From: Saul Kent <> Subject: Comments By Author Here are comments about Barry Sear's Anti-Aging Zone book by Ivy Greenwell, who wrote the review of his book for Life Extension Magazine. ---Saul Kent "From the start, there has been a misunderstanding of Barry Sears as just another weight-loss guru. Sears is in fact interested in a life-long anti-aging diet, one that would be an essential tool for maximizing health and longevity. In addition, it is important to emphasize that Sears by no means limits anti-aging regimen simply to the right diet. Stress reduction and moderate exercise are also very important components of his program. One could even argue that Sears is in fact fairly conservative in his recommendations, and not at all the flaming extremist portrayed by his opponents. In my correspondence with Bill Lawren, the co-author of Sears' first book, I was particularly struck by Lawren's view of Sears as a conservative. "I think the main point in Sears' new book is the need for calorie restriction without hunger. Based on everything I heard during the 1999 AGE conference in Seattle, there is profound scientific consensus on calorie restriction being the only known effective means of life span extension. While the primate calorie restriction studies are not yet concluded, preliminary results unquestionably indicate a slower rate of aging in calorie-restricted monkeys. Thus, Sears seems to be correct in advocating calorie restriction. He also proposes a way of practicing such calorie restriction so that one does not feel hungry, but instead enjoys more energy and well-being than before. Those who have tried the kind of low-glycemic diet that Sears proposes generally agree that it is workable. Increasing the amount of protein and healthy fats while decreasing high-glycemic carbohydrates does appear to lead to greater satiety and voluntary lower calorie intake. The scientific support for low-glycemic diet is growing. High blood sugar and chronic high insulin levels are generally recognized as correlates of faster aging. "Sears also suggests consuming "copious amounts of vegetables." He absolutely insists that most of our carbohydrates should come from vegetables. These substitute for high-glycemic processed grain products, so prevalent in the Western diet. Surely there is nothing controversial about promoting vastly more vegetable consumption. The controversy appears to lie in whether we lose anything by excluding refined carbohydrates such as cornflakes, most kinds of bread, mashed potatoes, or pasta. Sears agrees that a certain percentage of people appear to be genetically protected against developing insulin resistance, and for them a low-glycemic diet may not be critical. Most of us, however, would be vastly better off eating more broccoli and less bread and sugary snacks or any other food that significantly raises our blood sugar and insulin levels. Again, lecture after lecture at the AGE conference affirmed that the insulin signaling pathways as crucially involved in determining the rate of aging. A dramatic drop in insulin is one of the first effects of calorie restriction. "Another important point in The Anti-Aging Zone is the huge role of inflammation in aging and various major aging-related diseases, and thus the need to counteract inflammation. Whether fish oil (or, more technically, EPA) is as supremely important as Sears claims may be debatable, but there is little doubt that some powerful anti-inflammatory agent(s) should be taken if one is serious about slowing down aging. Again, when it comes to omega-3 fatty acids, evidence in their favor is pretty overwhelming. Sears is hardly a dietary radical when he encourages readers to consume more fish. "I readily concede that the exact percentage of macronutrients, and the (insulin? eicosanoid?) mechanism behind the effectiveness of calorie restriction remain to be elucidated. Sears should be more cautious and avoid sweeping statements, especially when it comes to the complex mechanisms of aging. Actually, this book already IS more cautious and much less dogmatic-sounding than the Zone book; it sees the suggested percentages of macronutrients more in terms of a range rather than any absolute numbers. "Sears has also added the need to lower cortisol, and not just insulin -- I think this is also well supported. There are no obese centenarians but the underlying common trait appears to be mainly a sunny, affectionate, stress-resistant personality rather than any kind of "centenarian diet." It can also be argued that nothing can overcome the primacy of genetics in longevity. Yet few doubt that calorie restriction can extend healthy life span even for those not blessed with "centenarian genes." "Time will show to what extent Sears is correct. We can take it for granted that he is not 100% correct when it comes to details, but that is excusable in any pioneer. Our knowledge is only partial. Nevertheless, a lot of solid evidence points to the validity of calorie restriction and low-glycemic diet, and each year this evidence is growing. Since a calorie-restricted, low-glycemic, vegetable-rich diet is in the main what Sears advocates, together with omega-3 fatty acids, stress reduction and moderate exercise, he is hardly an extremist. Within a decade or two, he'll probably be perceived as "mainstream," or even conservative. "I suspect that most of his opponents have not bothered to read his new book and/or do not understand his message. Another problem may be a negative attitude toward calorie restriction. To this, I'd like to say, "Try it, you'll like it." Calorie restriction need not be extreme to produce health benefits. Furthermore, if done correctly, with adequate protein and fat, it appears to be an amazingly satisfying and energizing way of eating. As for stress reduction and moderate exercise, these need no defense. Sears is not "far out." On the contrary, he appears quite moderate in his approach. " Rate This Message: http://www.cryonet.org/cgi-bin/rate.cgi?msg=13276