X-Message-Number: 13368
Date: Tue, 7 Mar 2000 06:02:41 -0500
From: Thomas Donaldson <>
Subject: CryoNet #13364 - #13366

Hi again

It is interesting that de Gray, the author of the book discussed by
Ettinger, has noticed that deprenyl actually has experiments showing
an increase in MAXIMUM lifespan. That is actually true; and other
drugs affecting lifespan also have that characteristic, though not
all of them.

The statistics required to establish that a drug treatment increases 
MAXIMUM lifespan is much more extensive than that needed to simply
show that it increases average lifespan --- mainly because in most
experiments only a few animals come close to maximum lifespan,
and we need more than a few to establish whether or not a drug will
increase maximum lifespan.

I will try to obtain this book myself, though I personally am dubious
that oxidation accounts for all the breakdowns of aging. One problem
with such a theory is that it must also account for other changes
that happen with aging. I'm hardly claiming that oxidation does not
account for SOME significant changes, only that it is not the whole
story.

			Best and long long life to all,

				Thomas Donaldson

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