X-Message-Number: 13825
Date: Fri, 2 Jun 2000 08:46:36 -0700 (PDT)
From: Doug Skrecky <>
Subject: lysine protects against brain anoxic damage

  Hong-Ping G.  Bao-Shan KU.
  Department of Pharmacology, Beijing Medical University, PR China.
  Neuroprotective effect of
  L-lysine monohydrochloride on acute iterative anoxia in rats
  with quantitative analysis of electrocorticogram.
  Life Sciences.  65(2):PL19-25, 1999.
  Lysine is one of the indispensible amino acids and
  L-lysine monohydrochloride (LMH) is widely available to
  public as a nonprescription oral supplement. Potential clinical usefulness of
  oral LMH supplements has been indicated in stroke, hypertension, and seizure
  induced by pentylenetetrazole (PTZ), etc. We compared the
  effects of LMH and flunarizine on the
  Electrocorticogram (EcoG) of rats intragastrically administered 1 hour before
  anoxia. LMH dose-dependently prolonged the time reaching
  the lowest ECoG average amplitude after anoxia and decreased
  the recovery time after recirculation in both 0.63 g/kg and
  1.26 g/kg groups. There was significant difference between
  the LMH- and saline-pretreated groups but no significant
  difference between the 1.26 g/kg LMH- and 2.5 mg/kg
  flunarizine-pretreated groups. The difference was not
  significant in the 2.52 g/kg group. The
  ECoG average amplitude did not reach isoelectric point and
  the lowest average amplitude was 10 percent of that of
  nomoxia in the 1.26 g/kg LMH-pretreated group during 2-min
  anoxia. The average amplitude pretreated with LMH (0.63 and
  1.26 g/kg) was lower than that of those pretreated with saline and
  flunarizine. The results tend to indicate that LMH can
  protect brain cells against anoxia by means of providing energy, reducing
  cerebral metabolic rate and inhibiting the
  effect of the excitable amino acids.

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