X-Message-Number: 14123
Date: Wed, 19 Jul 2000 11:14:05 -0700 (PDT)
From: Doug Skrecky <>
Subject: apoB is extremely low in Japanese Centenarians

  [Lipid and lipoprotein
  profile of Japanese centenarians--high prevalence of hypo
  beta lipoproteinemia]. [Japanese]
  Nippon Ronen Igakkai Zasshi - Japanese Journal of Geriatrics.  34(3):202-8,
  1997 Mar.
  To study the relationship between lipids and longevity, we
  examined the level of serum lipids and
  apolipoproteins, and the susceptibility of low density
  lipoprotein (LDL) to oxidation of 45 centenarians (15 men,
  30 women, mean age 101.1 +/- 1.4) living in the Tokyo metropolitan area. The
  average levels of total cholesterol (TC), of LDL-C of high-density
  lipoprotein cholesterol (HDL-C), and of
  apolipoproteins A1 and B were significantly lower in
  centenarians than in healthy middle-aged controls. The frequency of
  hypobeta-lipoproteinemia (apoB < 60 mg/dl) in centenarians
  was almost ten times as high as in controls. The time course of
  copper-mediated LDL, oxidation (assessed by monitoring 234 nm diene
  absorption (lag time)) did not significantly differ between the two groups.
  Analysis of LDL subfractions by non-denaturated gradient-gel electrophoresis
  showed a predominance of large, buoyant LDL particles (pattern A) in 75%, and
  a predominance of small dense LDL particles (pattern B) in 25% of
  centenarians. We also assessed activities of daily living (ADL) and cognitive
  function in the centenarians. Centenarians were divided into two groups
  according to the median ADL score, and were classified into five groups with
  a scale clinical dementia. In subjects with good ADL scores, the mean
  concentration of HDL-3-C was significantly higher than in those with poor ADL
  scores. Average levels of HDL-C were also significantly lower in subjects
  with moderate or severe dementia than in those with normal cognitive
  function. These findings suggest that centenarians have protective phenotypes
  of lipids and lipoproteins that protect
  them from atheroscierosis.

Rate This Message: http://www.cryonet.org/cgi-bin/rate.cgi?msg=14123