X-Message-Number: 14346
Date: Sat, 19 Aug 2000 17:48:11 -0700 (PDT)
From: Doug Skrecky <>
Subject: ramipril may be best for lowering blood pressure

  Ramipril vs captopril in mild to moderate
  Journal of the Association of Physicians of India.  42(2):120-3, 1994 Feb.
  Ramipril 5 mg once daily was compared to
  Captopril 50 mg twice daily in a randomised, double-blind,
  parallel group study in 60 patients with a diastolic blood pressure between
  95 to 120 mmHg over a period of 2 months. Both drugs in the dose regimen used
  in this study exerted a similar anti-hypertensive effect at the end of 2
  months of treatment resulting in a fall of supine diastolic blood pressure
  with Ramipril = 19.27 +/- 3.34 mmHg and
  Captopril = 19.15 +/- 2.63, in patients receiving the drugs
  without the diuretic. The mean fall in supine diastolic blood pressure 4
  hours after the first dose of Ramipril was 6.5 mmHg and
  Captopril 8 mmHg. None of the patients developed first dose
  hypotension or orthostatic hypotension and there was no significant
  alteration of the heart rate in either group. The serum K+ levels remained
  unchanged in both groups of patients. Both drugs were well tolerated and
  there were no adverse effects observed on the liver, kidney, blood sugar or
  haemopoietic system. Based on the results of this study, it can be concluded
  that the antihypertensive efficacy of 5 mg ramipril in a
  once daily dose is equivalent to 50 mg captopril given twice
  daily. However an appreciably greater number of patients reported improvement
  in the "quality of life' parameters with ramipril as
  compared to captopril. Thus for the routine treatment of
  mild to moderate arterial hypertension, ramipril offers
  reliable antihypertensive efficacy in a once daily dose, thereby helping to
  improve patient compliance and making the treatment more economical.

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