X-Message-Number: 14519
From: "John Clark" <>
Subject: An anti aging pill?
Date: Fri, 22 Sep 2000 11:28:35 -0400

In today's (Sept 22)  issue of Science Dr. Leonard Guarente reports that he's

found exactly why caloric restriction leads to longer life; at least he's found 
mechanism that works yeast and strongly suspects the same thing is true of all

life. Caloric restriction has extend the life of every species it has been 
tested in.

The key is a gene called SIR2 , the protein it produces clads to parts of the 
DNA helix,

covering it up and in effect turns off other genes that are supposed to be 
turned off.

But for the gene to make this cladding protein it needs a substance called NAD, 
and it

turns out NAD is also used in glucose metabolism, so if you eat a lot there is 
less NAD
available to make this very important cladding protein.

There is talk of a pill. Geneticist Tomas Prolla referring to life extension 
"I don't think a 30 to 40% range should be considered some kind of maximum.

      John K Clark        

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