X-Message-Number: 14546
Date: Mon, 25 Sep 2000 22:07:53 -0700 (PDT)
From: Doug Skrecky <>
Subject: 1,3-butanediol protects brain from hypoxia

  Changes in extracellular and
  rat brain tissue
  concentrations of D-beta-hydroxybutyrate
  after 1,3-butanediol treatment.
  Journal of Neurochemistry.  62(1):223-6, 1994 Jan.
  1,3-Butanediol (BD) treatment was previously shown to produce a dose-related
  increase of the plasma levels of D-beta-hydroxybutyrate
  (BHB) and to protect brain tissue against
  hypoxia and ischemia. The purpose of this study was to test whether
  BD-induced hyperketonemia was associated with changes in
  brain extracellular and
  tissue concentrations of BHB.
  Changes in extracellular levels of BHB were
  continuously monitored in anesthetized rats before and after
  intraperitoneal injection of BD (25 mmol/kg), using intracerebral
  microdialysis coupled to online analysis of BHB in the dialysate. Cortical
  tissue concentrations of BHB were
  determined in control and BD-treated rats (25 and 50
  mmol/kg, i.p.) after freezing of the brain in situ.
  Butanediol produced a rapid increase in dialysate levels of BHB, with a
  linear relationship between dialysate and plasma BHB
  concentrations (r = 0.81, p < 0.001). In contrast, and
  although brain tissue levels of BHB were
  markedly increased after BD treatment, they were not related to the plasma
  concentration of BHB. Our results suggest that BHB produced
  from BD did not accumulate in brain and that BD protects
  against hypoxia or ischemia by increasing brain BHB

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