X-Message-Number: 14634 From: Date: Sat, 7 Oct 2000 12:58:22 EDT Subject: oops! + coacervats Sorry, for the preceeding posting: it was a personnal message, not intended for cryonet. Thanks god, the second, giving the secret of making cheap H-bombs was intercepted by the NSA :-) Now, the question of the day: It seems, many good cryoprotectants are very viscous. Has anybody tried to load them in coacervats (sorry, this is the french name, I don't know the english translation). They are small vesicles similar to cell wall and exploited in some health care products. Not only this would permit to use very viscous products, but they can be taged with antibodies, so that they fuse with a given cell population. The cargo is delivered inside the cell, so that the requested amount of cryoprotectant in the general blood system is reduced (less toxicity). the cryoprotectant inside the coacervats may be different of the one in the general solution, so one product may be used inside the cells and another outside. These vesicles may be produced in a ultrasound sonicator, a device whose the cost is in the "kilobuck" range. The experimentation seems so afordable... If it has not been done, why? Yvan Bozzonetti. Rate This Message: http://www.cryonet.org/cgi-bin/rate.cgi?msg=14634