X-Message-Number: 14634
From: 
Date: Sat, 7 Oct 2000 12:58:22 EDT
Subject: oops! + coacervats

Sorry, for the preceeding posting: it was a personnal message, not intended 
for cryonet.  Thanks god, the second, giving the secret of making cheap 
H-bombs was intercepted by the NSA  :-)

Now, the question of the day:
 It seems, many good cryoprotectants are very viscous. Has anybody tried to 
load them in coacervats (sorry, this is the french name, I don't know the 
english translation). They are small vesicles similar to cell wall and 
exploited in some health care products.

Not only this would permit to use very viscous products, but they can be 
taged with antibodies, so that they fuse with a given cell population. The 
cargo is delivered inside the cell, so that the requested amount of 
cryoprotectant in the general blood system is reduced (less toxicity). the 
cryoprotectant inside the coacervats may be different of the one in the 
general solution, so one product may be used inside the cells and another 
outside.

These vesicles may be produced in a ultrasound sonicator, a device whose the 
cost is in the "kilobuck" range. The experimentation seems so afordable... If 
it has not been done, why?

Yvan Bozzonetti.

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