X-Message-Number: 14684
From: 
Date: Thu, 12 Oct 2000 11:49:48 EDT
Subject: Re:liposomes

In Message #14642
From: Keith Rene Dugue <>
I see:
<< I am not sure how well liposomes function at low 
 >temperatures. Anyway, some chemicals like alcohols affect liposome 
 >stability.
> 
> I believe the major task at hand is to prove to some degree that memory 
> systems can be preserved at cryogenic temperatures within the research 
> budget available.
> 
> 
> Keith R. Dugue
  
I was interested in the subject because:
- liposomes may be made (and tested) at low cost,
-They open the way to low cost cryoprotectants,
- Whith them there is (at least) the possibility of "hot" cryonics, may be at 
carbonic ice temperature.
- A long term possibility is to target with antibodies each cell population 
with a specific coctail.
-Liposomes can deliver some nanodevices inside cells, for example a chaperone 
complex with some chemical energy to run it (ATP)

The first reserch in that domain could be done at 21CM if they have the basic 
componment to do it or it could be an interesting new domain for another 
organization looking for low cost researches.

To prove that memory is indeed preserved may ask in the end that a full brain 
is reversibly frozen and thawed... Not a smallobjective. Well, if it can be 
done on current budget, I'll subscribe to that objective without problem (who 
don't?:-)

I may try to do some simple experiments with liposomes if nobody else want to 
perform them. My budget is limited and I don't to spent it on something 
already done elsewhere.

Yvan Bozzonetti.

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