X-Message-Number: 16667
Date: Sun, 24 Jun 2001 11:06:10 -0700 (PDT)
From: Doug Skrecky <>
Subject: glycerol and arginine

  Role of nitric oxide in glycerol-induced acute renal failure
  in rats.
  Nephrology, Dialysis, Transplantation.  9 Suppl 4:78-81, 1994.
  EDRF results from the metabolism of L-arginine. N-omega-nitro-L-arginine is a
  nitric oxide synthase inhibitor (L-arginine competitive inhibitor). Acute
  renal failure was induced by i.m glycerol (50%) 5 ml/kg bw.
  L-arginine: 3 mg/kg bw/min for 60 min before and 60 min after
  glycerol administration. L-arginine inhibitor (150
  micrograms/kg bw/min for 120 min). Cin, Cpah and FENa% were measured
  immediately or 24 h after glycerol (mean of three periods of
  20 min). A second series of similar experiments was done in dehydrated (16 h)
  rats with a high dose of glycerol (50% solution, 10 ml/kg
  bw). L-arginine ameliorates the severity of ARF immediately after
  glycerol administration and enhances the recovery of
  glycerol-induced ARF. The L-arginine inhibitor resulted in a
  more severe ARF. Urinary cGMP decreased significantly after
  glycerol administration. It is concluded that nitric oxide
  has an important pathogenetic role in the glycerol induced

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