X-Message-Number: 17440
Date: Sun, 2 Sep 2001 01:28:07 -0700 (PDT)
From: Doug Skrecky <>
Subject: glycerol rhabdomyolysis: what does not kill me makes me stronger

Title
  Effects of changes in plasma volume on fatal rhabdomyolysis
  in the rat induced by glycerol injections.
Source
  Journal of Basic & Clinical Physiology & Pharmacology.  3(3):223-37, 1992
  Jul-Sep.
Abstract
  Rhabdomyolysis can be fatal in both experimental animals and
  man, but very little is known of the factors causing increased mortality in
  rhabdomyolysis. The aims of this study were to create an
  animal model of fatal rhabdomyolysis in rats by a
  glycerol injection into the leg muscle, and to elucidate
  some of the factors affecting mortality as a result of
  rhabdomyolysis formation. In this study, two factors which
  can result in increased mortality in rats as a result of
  glycerol injection, were examined. These factors include
  varying doses of 50% glycerol (0.5-2 ml/100 g) and various
  stages of dehydration prior to glycerol injection.
  Dehydration was induced by 1: chronic dehydration, in which the rats
  underwent water deprivation for a period of 24 to 72 hours prior to injection
  of glycerol; 2: acute dehydration, by the induction of
  either diuresis, by injecting sucrose (200-600 mg/100 g) to the femoral vein,
  or hemorrhage (0.7-2.1 ml/100 g). The results demonstrate that the mortality
  rate in rats increased in all three models of dehydration as the dose of
  glycerol injected to the rats increased (above a dose of
  0.75 ml/100 g) and as the extent of dehydration increased. Use of a blood
  substitute before or after glycerol injection in order to
  compensate for the loss of body fluids did not increase the survival rate of
  the glycerol-injected rats. In contradistinction, rats
  treated with non-lethal doses of glycerol exhibited
  substantial resistance to a second lethal dose of glycerol,
  injected two weeks following the first injection.

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