X-Message-Number: 18475
From: "John de Rivaz" <>
Subject: CryoNet #18464 (flu vaccines and stroke)
Date: Sun, 3 Feb 2002 16:08:30 -0000

Yes, the bit I posted was exactly as reported on Infobeat. Unfortunately
there are no links to other sources to check in more detail what actually
happened and whether the research was properly conducted in the manner Dr
Harris suggested it should have been.

I have tried the University mentioned, http://www.sigu7.jussieu.fr/
without result.

The following was from
To get the full article costs $15 - maybe some professional readers of
cryonet have access and can comment.

The email address of one of the authors is given in this abstract, however I
feel it would be inappropriate of me to forward Dr Harris' comments directly
to this author. I would however be most interested if Dr Harris has the time
and inclination so to do and then post the results of the interaction to us
here on CryoNet. As a layman's  cursory glance it would seem that the
authors have performed some but not nearly enough of the precautions that Dr
Harris recommends as leading to a worthwhile and reliable result.

Association Between Influenza Vaccination and Reduced Risk of Brain
Philippa Lavall e, MD; V ronique Perchaud, MD; Marion Gautier-Bertrand;
David Grabli, MD; Pierre Amarenco, MD

From the Department of Neurology and Stroke Center and the Formation de
Recherche en Neurologie Vasculaire (Association Claude Bernard), Bichat
Hospital, Denis Diderot University (P.L., V.P., D.G., P.A.), and INSERM Unit
360, La Salp tri re Hospital (M.G-B.), Paris, France.

Correspondence to Pierre Amarenco, MD, Department of Neurology and Stroke
Center, Bichat Hospital, 46 rue Henri Huchard, 75018 Paris, France. E-mail

Background and Purpose  Because infections subsequent to influenza may play
a role in promoting the complications of atherosclerotic disease and may
also induce hypercoagulation, we hypothesized that influenza vaccination may
protect against brain infarction.

Methods  During the influenza epidemic period we studied 270 subjects,
including 90 consecutive patients older than 60 years admitted to the
hospital for brain infarction and 180 population-based controls, matched for
age, sex, and district of residency in Paris. We conducted a structured
interview on whether they had been vaccinated during the last influenza
vaccination campaign or every year during the 5 last years.

Results  We found significantly fewer vaccinated subjects during the last
vaccination campaign among patients with brain infarction than among
controls (46.7% versus 59.4%; P=0.036) and fewer patients vaccinated every
year during the last 5 years (41.1% versus 56.1%; P=0.017). After adjustment
for age, traditional risk factors, and recent use of antibiotics, the risk
of stroke was reduced in the subjects vaccinated during the year of the
study and in those vaccinated during the last 5 years, with an odds ratio of
0.50 (95% CI, 0.26 to 0.94; P=0.033) and 0.42 (95% CI, 0.21 to 0.81;
P=0.009), respectively. Similar associations were observed in cases and
controls free of previous cardiovascular history. Subjects younger than 75
years and subjects free of risk factors or in high social class were
significantly less often vaccinated than controls.

Conclusions  Influenza vaccination may protect against brain infarction by
reducing infections or may identify a subgroup of patients at low risk for
stroke because of a better lifestyle. These results give rise to a new
hypothesis for research into stroke prevention.

Key Words: cerebral infarction   infection   influenza vaccine   stroke

I feel it is important to those interested in extending lifespan to be aware
of the risks associated with infections diseases if such risks exist - they
may be more than a mere irritation.

Sincerely, John de Rivaz:      http://www.deRivaz.com
my homepage links to Longevity Report, Fractal Report, music, Inventors'
report, an autobio and various other projects:
http://www.autopsychoice.com - http://www.cryonics-europe.org -

Rate This Message: http://www.cryonet.org/cgi-bin/rate.cgi?msg=18475