X-Message-Number: 19550
Date: Thu, 18 Jul 2002 00:23:33 EDT
Subject: PARP Inhibition and cryonics

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In a message dated 7/17/2002 2:01:23 AM Pacific Daylight Time, Brent Thomas 
> Since cryonics is an event which is (to put it mildly) traumatic to all 
> cells (neurons included) and we've got a special interest in preserving 
> nerve function then it would be to our advantage to look into process 
> mechanics such as this and investigate what types 
> of 'additives' can be introduced to cryprotectant solutions which will 
> serve not as a cryo protectant but instead as a cell protectant (structure, 
> integrity, operation, mechanics etc). some form of PARP antagonist which 
> would sequester trauma induced PARP and prevent AIF production would be an 
> excellent start...

PARP inhibition was a an integral part of the 21st Century Medicine (21CM) 
canine resuscitation protocol as far back as the late 1990s. In fact, I 
believe that I was the first person to appreciate the importance of PARP 
inhibition in resuscitation after prolonged periods of cardiac arrest and use 
pharmaclogical intervention to inhibit it. Suspeneded Animation, Inc., (SA) 
of Boca Raton, FL is now in the process of preparing updated 
cerebroprotective and systemically protective post-cardiac arrest medications 
for use by SA and Alcor on human cryopreservation patients. We completed 
preparation and packaging of the PARP inhibitor (a different and superior one 
to that used by 21CM) on Monday. The drugs should be distributed to several 
locations by the end of next week. The PARP inhibitior is only one of about 
20 drugs used in the protocol. One new addition apparently has the ability to 
reverse rigor in humans. This is the first time I have ever observed any drug 
to effefctively reverse rigor mortis. 

Mike Darwin,
Cryopreservation Team Leader
Suspended Animation, Inc.


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