X-Message-Number: 19597
Date: Tue, 23 Jul 2002 13:09:55 -0700 (PDT)
From: Scott Badger <>
Subject: CR mimetics

It may be old news to some, but I hadn't heard about
this work. You get the beneficial life extending
effects of caloric restriction ... without starving.

Here's a current Scientific American article
discussing it.


Also, here's an abstract that suggests anti-diabetics
such as metformin may be effective CR mimetics.


An enthusiastic article on metformin by Ward Dean, MD


Interesting. Decreased sensitivity to insulin is so
common among older adults that almost all in their 40s
or over are considered barely sub-clinical for

Note to those who consider taking metformin, consider
supplementing with generous doses of B-12 and monitor
your insulin level to avoid hypoglycemia.

Does anyone have useful experience or knowledge in
this area?

Scott Badger

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