X-Message-Number: 19969
Date: Mon, 2 Sep 2002 13:25:41 -0700 (PDT)
From: Doug Skrecky <>
Subject: addendum to Thomas Donaldson

Message #19959 From: Thomas Donaldson <>
>Some time ago I wrote a book, A GUIDE TO ANTIAGING DRUGS, ...
>criteria are basically simple: it must be shown to prolong the lifespan'
>of some healthy strain of mammal. I do not accept work with flies,
>worms, or clearly unhealthy animals.
    After working with flies for some time, I have to agree with Thomas.
If anything I am more conservative, and regard that the only true measure
of man ['s longevity] is man.
    Published longevity research needs to be taken in context, to be
understood. From the human context drosophila melanogaster flies are an
animal model not of human "aging", but of Huntington's disease. Similarly
C57B6J mice are not a good model of human "aging" either, but do serve as
a good animal model for lymphoma cancer.
    IMHO, human "aging" itself is too general a term to be very useful.
There do occur a variety of age associated ills in humans, but these
pretty much have to be specified (such as sarcopenia) before intelligent
comments can be made.

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