X-Message-Number: 20421
Date: Sat, 9 Nov 2002 05:54:11 -0800 (PST)
From: Doug Skrecky <>
Subject: 72'nd update on fly longevity experiments

    This is the 72'nd update of my fly longevity experiments. Average
temperature was 24.7 C during this run. Here I retest bergamot,
CDP-choline, and citrulline at some higher doses.
    The 1/4 tsp dose of bergamot leaf again increased survival. A
published experiment found that black tea also increased survival due to
the presence of a volatile iron chelator, which prevented iron
accumulation in fly tissues. I suspect that this volatile iron chelator,
which is not present in green tea, may have been derived from the bergamot
leaf, which is added to some black teas. Since I used bergamot leaf
powder, rather than brewing a tea, the leaf powder may have released this
voltaile iron chelator gradually. At any rate, this is one theory
explaining  why bergamot appears to work at a low dose. The high dose
might be inducing a marginal iron deficiency.
    CDP-choline once again found the 500 mg dosage edging out the 250 mg
dose, but mild toxicity appears to have set in at the 1000 mg dose. The
1/2 tsp dose of citrulline yielded a positive hit.

Run #72                Percent Survival on Day
supplement              7  16 25 34 45 54 63
____________________________________________
control                93  89 61 25  7  0  -
bergamot leaf 1/4 tsp 100  86 81 62 19  0  -
bergamot leaf 1 tsp   100  63 58 32 16  0  -
CDP-choline 250 mg    100 100 65 30 15  0  -
CDP-choline 500 mg    100  75 71 46 11  0  -
CDP-choline 1000 mg    89  79 68 25  4  0  -
citrulline 1/2 tsp     96  91 87 61 26 17  0
citrulline 1 tsp      100  84 68 32  4  0  -

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