X-Message-Number: 20572
Date: Sun, 8 Dec 2002 19:42:29 -0800 (PST)
From: Doug Skrecky <>
Subject: 73'rd update on fly longevity experiments

    This is the 73'rd update of my fly longevity experiments. Average
temperature was 25.5 C during this run. Here mitochondrial
antioxidants/substrates are tested. I also recently found another source
for coconut juice, and with an eye to making (colorless) coconut juice a
standard addition I test out this lastest batch.
    The control had a very poor survival, possibly because of viral
contamination. Acetyl-L-carnitine (ALC) by itself did nothing, and
inconsistent effects were obtained with lipoic acid by itself. However the
combination of ALC 125 mg & lipoic 25 mg yielded a more "normal" survival
curve. I've obtained large increases in survival before, but it has always
been when the control bottle showed poor results. I'm skeptical, but
none-the-less will try ALC, and lipoic acid again.
    The negative result with coconut juice was a big surprise, as this
type of fruit juice has repeatedly exhibited a survival promoting effect
in the past. However the coconut juice used this time is from a different
source, and possibly heat treatment may have deactivated the juice. This
coconut juice is looked at again in the next run.

Run #73                         Percent Survival on Day
supplement                  6 15 24 36 43 48 53 59 66 71 78 83
______________________________________________________________
control                    83 54 21  4  0  -  -  -  -  -  -  -
coconut juice              80 30  8  3  0  -  -  -  -  -  -  -
ALC 125 mg                 90 45  5  3  0  -  -  -  -  -  -  -
ALC 125 mg + lipoic 25 mg  92 78 62 48 29 12 11  8  5  3  2  0
ALC 500 mg                 78 56 22  0  -  -  -  -  -  -  -  -
ALC 500 mg + lipoic 100 mg 77 40 20  0  -  -  -  -  -  -  -  -
lipoic 25 mg               80  4  0  -  -  -  -  -  -  -  -  -
lipoic 100 mg              85 40 30 10  5  5  0  -  -  -  -  -

Rate This Message: http://www.cryonet.org/cgi-bin/rate.cgi?msg=20572