X-Message-Number: 22444
Date: Sun, 31 Aug 2003 12:26:02 -0700 (PDT)
From: Doug Skrecky <>
Subject: NAD & Sir

In Message #22441 "michaelprice" <> wrote:

>  NAD (the coenzyme form of vitamin B3) is a
> substrate for sirtuins, which consequently up-regulates sirtuin
> activity.
I'm told it does not. NAD is not a limiting factor for Silent Information
Regulator activity under normal circumstances. Nicotinamide can reduce SIR
activity by blocking the NAD site, but niacin has no effect.

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