X-Message-Number: 22726
Date: Fri, 24 Oct 2003 11:56:31 -0700 (PDT)
From: Jeff Davis <>

Subject: Re: CryoNet #22714: dietary supplement abolishes age-related cognitive 

Message #22714 Date: Thu, 23 Oct 2003 05:17:41 -0700
(PDT), from Doug Skrecky <> 

Exp Biol Med (Maywood). 2003 Jul;228(7):800-10.
A  dietary supplement abolishes age-related cognitive
decline in transgenic mice expressing elevated free
radical processes.

The above sounds an awful lot like Bruce Ames work
with L-acetyl carnatine.  Note that the item never
actually identifies the "dietary supplement".

The below is from:


Note the last line.
"The main thrust of research in the lab is the study
and therapeutic manipulation of metabolic dysfunction,
for the purpose of restoring and enhancing human
health. For instance, we have characterized the
age-related oxidative decay of mitochondria in
laboratory rats, and have restored function in old
rats by feeding high levels acetyl carnitine and
lipoic acid [1-3, 7]. Mechanistic studies suggest that
the observed drop in mitochondrial function may result
from a decreased Km in key enzymes that act on these
metabolites, and that this drop may be overcome
through supplementation [1]. In addition to reversing
the increase of many biochemical markers of oxidative
damage in old rats, these supplements appear to
restore cognitive function to levels seen in young
animals. ..."

Best, Jeff Davis

   "Everything's hard till you know how to do it."
                           Ray Charles

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