X-Message-Number: 22726 Date: Fri, 24 Oct 2003 11:56:31 -0700 (PDT) From: Jeff Davis <> Subject: Re: CryoNet #22714: dietary supplement abolishes age-related cognitive decline Message #22714 Date: Thu, 23 Oct 2003 05:17:41 -0700 (PDT), from Doug Skrecky <> Exp Biol Med (Maywood). 2003 Jul;228(7):800-10. A dietary supplement abolishes age-related cognitive decline in transgenic mice expressing elevated free radical processes. <snip> ----------------------------- The above sounds an awful lot like Bruce Ames work with L-acetyl carnatine. Note that the item never actually identifies the "dietary supplement". The below is from: http://ehscenter.berkeley.edu/people/ames.htm Note the last line. "The main thrust of research in the lab is the study and therapeutic manipulation of metabolic dysfunction, for the purpose of restoring and enhancing human health. For instance, we have characterized the age-related oxidative decay of mitochondria in laboratory rats, and have restored function in old rats by feeding high levels acetyl carnitine and lipoic acid [1-3, 7]. Mechanistic studies suggest that the observed drop in mitochondrial function may result from a decreased Km in key enzymes that act on these metabolites, and that this drop may be overcome through supplementation [1]. In addition to reversing the increase of many biochemical markers of oxidative damage in old rats, these supplements appear to restore cognitive function to levels seen in young animals. ..." Best, Jeff Davis "Everything's hard till you know how to do it." Ray Charles __________________________________ Do you Yahoo!? The New Yahoo! Shopping - with improved product search http://shopping.yahoo.com Rate This Message: http://www.cryonet.org/cgi-bin/rate.cgi?msg=22726