X-Message-Number: 22732 From: "Igor Artyuhov" <> References: <> Subject: Re: Dietary supplement abolishes age-related cognitive decline (CryoNet #22726) Date: Sat, 25 Oct 2003 23:49:32 +0400 > Message #22726 > Date: Fri, 24 Oct 2003 11:56:31 -0700 (PDT) > From: Jeff Davis <> > Subject: Re: CryoNet #22714: dietary supplement abolishes age-related cognitive decline [Sorry, skipped] > The above sounds an awful lot like Bruce Ames work > with L-acetyl carnatine. Note that the item never > actually identifies the "dietary supplement". The composition of the supplement they called AASUP (for anti-aging supplement) is published in the paper "A Dietary Supplement Abolishes Age-Related Cognitive Decline in Transgenic Mice Expressing Elevated Free Radical Processes" by J.A. Lemon, D.R. Boreham, and C.D. Rollo in: Experimental Biology and Medicine 228: 800-810 (2003). Since it includes 31 components it was hardly possible to list them all in an abstract. Here is Table 1 from the paper: Table I. Formulation of a Dietary Supplement Designed to Reduce Oxidative Stress and Inflammation, Maintain Membrane and Mitochondrial Integrity, and Enhance Insulin Sensitivity Vitamin B1 0.72 mg/day Vitamin B3 0.72 mg/day Vitamin B6 0.72 mg/day Vitamin B12 0.72 mcg/day Vitamin C 3.6 mg/day Vitamin D 2.5 IU/day Vitamin E 1.44 IU/day Acetyl L-Carnitine 14.4 mg/day Alpha-Lipoic Acid 0.72 mg/day ASA 2.5 mg/day Beta Carotene 50.0 IU/day Bioflavinoids 4.32 mg/day Chromium Picolinate 1.44 mcg/day Cod Liver Oil 5.04 IU/day CoEnzyme Q10 0.44 mg/day DHEA 0.15 mg/day Flax Seed oil 21.6 mg/day Folic Acid 0.01 mg/day Garlic 21.6 mcg/day Ginger 7.2 mg/day Gingko Biloba 1.44 mg/day Ginseng (Canadian) 8.64 mg/day Green Tea Extracts 7.2 mg/day L-Glutathione 0.36 mg/day Magnesium 0.72 mg/day Melatonin 0.01 mg/day N-Acetyl Cysteine 7.2 mg/day Potassium 0.36 mg/day Rutin 0.72 mg/day Selenium 1.08 mcg/day Zinc (chelated) 0.14 mg/day Vitamin brands are: Cell Life; Jamieson vitamins; Jarrow Formulas; Lifebrand; Natural Factors; Naka; Promatrix; Swiss vitamins; Vitamin Power Inc. One should remember that the experiment was performed with transgenic mice overexpressing growth hormone (TGM) and its results are NOT necessary applicable to wild-type humans. Rate This Message: http://www.cryonet.org/cgi-bin/rate.cgi?msg=22732