X-Message-Number: 23838
Date: Thu, 8 Apr 2004 20:19:05 -0700 (PDT)
From: Doug Skrecky <>
Subject: 132'nd update onfly longevity experiments
This is the 132'nd update of my fly longevity experiments. Average
temperature was 20.5 C during this run. Estimated maximal longevity using
the formula (363 - T*11.2) is 134 days.
Here I retest blacks teas, and coffee. These can all inhibit iron
availability, and possibly increase survival by limiting the growth of
iron dependant bacteria on the medium, and in the gut. I also take a
second look at peanut skin.
To no great surprise, both tea and coffee again offered some benefit,
with decaffeinated coffee offering the best results over-all. The null
results with resveratrol-rich peanut skin, are in agreement with my
earlier null results with resveratrol itself. After starting this run I
discovered an explanation for this lack of effect of resveratrol: ("A
Drosophila Homoloque of Sir2 Modifies Position-Effect Variegation but does
not Affect Life Span" Genetics 162: 1675-1685 December 2002.) In short the
powerful effect of resveratrol on (d)Sir2, can not be expected to affect
lifespan, because (d)Sir2 itself does not affect fly lifespan. Since yeast
lifespan is modulated by Sir2, then resveratrol does prolong yeast
lifespan. The biochemistry of aging is different in different species.
Run #132 Percent Survival on Day
supplement 19 28 33 40 49 60 69 76 83 91 97 101 107
__________________________________________________________________
control one 86 71 62 38 19 24 5 5 5 0 - - -
control two 80 60 56 56 36 8 8 0 - - - - -
black decaf tea 2 bags/L 94 75 69 66 47 28 22 13 6 6 0 - -
black decaf tea 4 bags/L 82 67 67 56 48 26 11 7 0 - - - -
+ peanut skin 2 tsp 88 88 85 70 52 27 15 6 3 3 0 - -
black decaf tea 10 bags/L 85 75 70 55 40 25 15 5 5 0 - - -
+ peanut skin 4 tsp 72 67 61 50 44 32 11 6 0 - - - -
coffee 2 tsp 87 80 73 73 73 47 40 27 13 7 7 7 0
coffee 4 tsp 79 71 71 64 43 43 7 7 0 - - - -
coffee decaf 2 tsp 94 94 78 72 56 33 33 33 11 6 0 - -
coffee decaf 4 tsp 95 86 76 76 67 52 52 38 19 10 5 5 0
peanut skin 1 tsp 88 84 72 68 36 12 4 0 - - - - -
peanut skin 2 tsp 75 67 67 42 42 33 17 0 - - - - -
peanut skin 4 tsp 63 53 37 26 16 11 0 - - - - - -
peanut skin raw 1 tsp 58 47 47 37 26 5 0 - - - - - -
peanut skin raw 2 tsp 61 61 61 61 39 33 17 6 0 - - - -
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