X-Message-Number: 24307
Date: Mon, 28 Jun 2004 22:11:40 -0700 (PDT)
From: Doug Skrecky <>
Subject: 141'st update on fly longevity experiments
This is the 141'st update of my fly longevity experiments. Average
temperature was 22.9 C during this run. Estimated maximal longevity using
the formula (363 - T*11.2) is 106 days.
Here I retest some amino acids at higher doses than previously. Lysine
can inhibit some glycation reactions, while tyrosine inhibits cellular
senescence of human fibroblasts grown in Eagle medium. (Experimental Cell
Research 1972, 566-568)
Bragging rights to last surviving fly this time went to a lysine
bottle. However, since this is due to a single fly living for a long time,
I am inclined to regard this as a fluke. Phenylalanine did appear to be
slightly beneficial, but most of the others were toxic to some degree.
Possibly the most interesting results were with high dose tyrosine.
(Unfortunately the low dose bottle was eventually destroyed by mold.)
Control flies had lost the ability to fly by the day 70 census. Although
tyrosine increased early mortality, flies did continue to "fly" till day
80. Although this could easily be a chance finding, it is still tempting
to speculate that this might be due to a slowing of motor neuron
degeneration.
Run #141 Percent Survival on Day
supplement 6 16 22 28 33 44 49 56 61 70 75 80 85 90 96
_______________________________________________________________
control one 95 81 71 71 71 62 48 33 33 10 0 - - - -
control two 97 78 72 72 67 47 19 17 8 0 - - - - -
lysine 1 gm 100 87 87 90 84 50 24 16 8 3 3 3 3 3 0
lysine 4 gm 90 77 73 50 43 0 - - - - - - - - -
ornithine 1 gm 100 77 73 73 70 40 30 20 13 0 - - - - -
ornithine 4 gm 100 77 71 62 29 3 0 - - - - - - - -
phenylalanine 1gm 100 96 87 91 91 65 52 35 17 9 4 0 - - -
phenylalanine 4gm 90 80 75 70 70 55 45 25 20 10 10 0 - - -
proline 1 gm 96 74 74 70 70 44 22 4 0 - - - - - -
proline 4 gm 100 96 96 96 88 54 29 13 0 - - - - - -
tyrosine 1 gm 68 64 55 55 55 50 46 27 14 0(mold) - - -
tyrosine 4 gm 67 60 60 57 50 47 43 27 23 7 3 3 0 - -
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