X-Message-Number: 24561
Date: Fri, 27 Aug 2004 10:24:34 -0700 (PDT)
From: Doug Skrecky <>
Subject: allose

[Too bad the sugar allose is too expensive to use...]   8(

J Hepatobiliary Pancreat Surg. 2004;11(3):181-9
D-Allose has a strong suppressive effect against ischemia/reperfusion
injury: a comparative study with allopurinol and superoxide dismutase.
 BACKGROUND/PURPOSE: D-Allose, a rare sugar, is one of the potent
inhibitors of ischemia/reperfusion injury of the rat liver. To
investigate the potency of this powerful agent we examined its effect
a gainst ischemia/reperfusion injury and compared it to that of
allopurinol and superoxide dismutase.
METHODS. Male Lewis rats were given water ad libitum preoperatively for
12 h and anesthetized by isoflurane inhalation anesthesia. Drugs were
administered through a polyethylene catheter inserted into the portal
vein for 2 h (D-allose), 10 min (allopurinol), or 5 min (superoxide
dismutase) before ischemia, and the livers were then subjected to 70%
ischemia, induced by crossclamping the vessels to the lateral and median
lobes of the liver for 90 min. Rats were divided into four groups: group
1, pretreated with vehicle (normal saline); group 2, treated with
D-allose; group 3, treated with allopurinol; and group 4, treated with
superoxide dismutase. The effects of the drugs were evaluated by liver
hemodynamics, neutrophil count, myeloperoxidase, liver enzymes, and
histological studies.
RESULTS. D-Allose improved liver hemodynamics (P < 0.001) and postischemic
animal survival (P < 0.05) significantly compared with the control group
and nonsignificantly compared with the allopurinol and superoxide
dismutase groups. Myeloperoxidase activity in the postischemic liver
tissue was decreased significantly (P < 0.05) by D-allose compared with
all other treatment and control groups. Neutrophil count was also
significantly (P < 0.05) decreased in the D-allose group compared with
than that in the control group, as well as the superoxide dismutase
group. Only D-allose produced a statistically significant decrease in the
level of liver enzymes, compared with levels in the control group.
CONCLUSIONS. The moderately protective effect of D-allose, which caused
no clinical side effects, is encouraging. D-Allose had the best
protective effect against neutrophil-related postischemic injury of the
liver tissue, followed by allopurinol and superoxide dismutase. However,
a more extensive study is needed to ensure the effects as well as the
mechanisms of the effect of this rare sugar.

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