X-Message-Number: 25230
Date: Sun, 5 Dec 2004 20:28:39 -0800 (PST)
From: Doug Skrecky <>
Subject: effortless weight loss on low AGE diet?

[Looks like it, at least if you're a rodent.]

Diabetes. 2002 Jul;51(7):2082-9
Improved insulin sensitivity is associated with restricted intake of
dietary glycoxidation products in the db/db mouse.
  Advanced glycation end products (AGEs), known promoters of diabetic
complications, form abundantly in heated foods and are ingested in
bioreactive forms. To test whether dietary AGEs play a role in the
progression of insulin resistance, C57/BL/KsJ db/db mice were randomly
placed for 20 weeks on a diet with either a low AGE content (LAD) or a
3.4-fold higher content of AGE (high AGE diet [HAD]), including
(epsilon)N-carboxymethyllysine (CML) and methylglyoxal (MG). LAD-fed mice
showed lower fasting plasma insulin levels throughout the study (P =
0.01). Body weight was reduced by approximately 13% compared with HAD-fed
mice (P = 0.04) despite equal food intake. LAD-fed mice exhibited
significantly improved responses to both glucose (at 40 min, P = 0.003)
and insulin (at 60 min, P = 0.007) tolerance tests, which correlated with
a twofold higher glucose uptake by adipose tissue (P = 0.02).
Compared with the severe hypertrophy and morphological disorganization of
islets from HAD-fed mice, LAD-fed mice presented a better-preserved
structure of the islets. LAD-fed mice demonstrated significantly
increased plasma HDL concentrations (P < 0.0001). Consistent with these
observations, LAD-fed mice exhibited twofold lower serum CML and MG
concentrations compared with HAD-fed mice (P = 0.02). These results
demonstrate that reduced AGE intake leads to lower levels of circulating
AGE and to improved insulin sensitivity in db/db mice.

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