X-Message-Number: 25358
Date: Sat, 18 Dec 2004 21:16:45 -0800 (PST)
From: Doug Skrecky <>
Subject: Cardiolipin may be a key regulator of aging

Biochem Biophys Res Commun. 2004 Oct 22;323(3):739-42
Cardiolipin induces premature senescence in normal human fibroblasts.
  Lipids seem to have various roles in cellular senescence. We found that
cardiolipin very sensitively inhibits growth of normal human fibroblasts,
whereas other phospholipids do not at 100 times higher concentrations.
Growth arrested cells showed morphology similar to those of normally
senesced cells and strongly induced senescence-associated
beta-galactosidase. Senescence markers such as the p21(waf1/sdi-1),
fibronectin, and collagenase-I genes were significantly upregulated by
cardiolipin. In addition, caldiolipin significantly increased in normally
senesced human fibroblasts leaving other phospholipids unaltered. These
results suggest that accumulation of cardiolipin is one of the causes for
replicative senescence.

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