X-Message-Number: 25504
From: 
Date: Sun, 9 Jan 2005 14:05:02 EST
Subject: p16 knockdown will cause cancer

p16 is a "checkpoint" protein, like p53. If cells detect damage, the levels 
of these proteins go up and eventually stop the cells from dividing. This is 

not a bad thing, though; it is a cancer control mechanism. You don't want cells
with damaged DNA to keep dividing!

Of course knocking down p16 makes cells grow longer in culture. That doesn't 
mean that you want to knock down your own p16!


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