X-Message-Number: 25997
Date: Sun, 10 Apr 2005 20:54:26 -0700 (PDT)
From: Doug Skrecky <>
Subject: 171'st update on fly longevity experiments
This is the 171'st update of my fly longevity experiments. Average
temperature was 21.5 C during this run. Estimated maximal longevity using
the formula (363 - T*11.2) is 123 days.
Low doses of white kidney (or canolini) beans have increased
longevity in several past runs. This run checks out a white
kidney protease inhibitor extract called phaseolamin 2250. A glycation
inhibitor related to thiamine called benfotiamine, and a muscle damage
inhibitor herb called rhodiola rosea fill out this run.
Not to any great surprise, both benfotiamine and rhodiola rosea
turned out to be duds. In the past other glycation inhibitors
(eg thiamin), and muscle damage inhibitors (eg bromelain) were found to
be inactive in altering fly longevity.
The fact that the "anti-obesity" extract phaseolamin turned out also
to be ineffective, makes me wonder what the active prolongevity
ingrediant(s) are in white kidney beans. Since cooked beans were tested,
about that can be said at this point, is that the active ingrediant(s)
is(are) heat stable.
Run #171 Percent Survival on Day
supplement 8 16 25 39 46 58 68 77 84 92 105 109
______________________________________________________________
control one 78 65 57 49 33 26 15 4 4 2 2 0
control two 87 65 61 48 29 13 10 7 3 0 - -
benfotiamine 80 mg 91 69 69 57 29 17 11 3 0 - - -
" 320 mg 97 73 70 63 60 13 3 0 - - - -
phaseolamin 125 mg 92 67 71 46 25 17 4 4 0 - - -
" 250 mg 95 57 48 24 14 10 5 5 0 - - -
" 500 mg 88 67 63 29 21 8 4 0 - - - -
" 1000 mg 87 57 47 23 13 3 3 3 0 - - -
rhodiola rosea 125 mg 84 63 63 50 44 13 6 3 0 - - -
" 500 mg 68 55 46 32 14 0 - - - - - -
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