X-Message-Number: 26114
Date: Sat, 30 Apr 2005 11:59:37 -0700 (PDT)
From: Doug Skrecky <>
Subject: 174'th update on fly longevity experiments

     This is the 174'th update of my fly longevity experiments. Average
 temperature was 21.6 C during this run. Estimated maximal longevity using
 the formula (363 - T*11.2) is 122 days.
     Choline alfoscerate exerts some neural protection in mammalian
 models, so some benefit on was expected on fly maximum survival, since
 motor neuron degeneration limits lifespan in flies. A low dose of
 pantothenic acid improved mean but not maximum survival in a published
 experiment. (Exp Gerontol 6: 133-151 1971) I interpret this result as
 action against pathogen induced mortality. Oyster mushroom has suppressed
 caloric intake. (Biochimica et Biophysica Acta 1474: 299-308 2000)
     Control longevity was very poor, which suggested pathogens were at
 work. Some short term benefit was seen for choline alfoscerate, but only
 two flies lived longer than the controls. As expected, low dose
 pantothenic acid proved to be somewhat beneficial. Oyster mushroom was
 also slightly beneficial.

 Run #174                    Percent Survival on Day
 supplement                  7 21 28 40 50 59 66 74 79 83 91
 ___________________________________________________________
 control one                91 67 53 24  7  4  0  -  -  -  -
 control two                87 65 60 32 14  0  -  -  -  -  -
 choline alfoscerate 63 mg  97 79 61 24  9  6  3  3  3  3  0
   "                125 mg  91 65 65 48 19  4  0  -  -  -  -
   "                250 mg  93 79 69 31 10  3  0  -  -  -  -
   "                500 mg 100 73 67 60 40 17  3  0  -  -  -
 oyster mushroom 4%         81 62 49 22 16  8  3  3  0  -  -
   "            10%         86 61 58 39 28  8  3  3  0  -  -
 pantothenic acid 63 mg     95 76 67 38 19 14 14  5  0  -  -
   "             250 mg     86 54 46 29 11  4  0  -  -  -  -

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