X-Message-Number: 26779 Date: Sun, 7 Aug 2005 13:49:47 -0700 (PDT) From: Doug Skrecky <> Subject: 186'th update on fly longevity experiments This is the 186'th update of my fly longevity experiments. Average temperature was 25.2 C during this run. Estimated maximal longevity using the formula (363 - T*11.2) is 81 days. The Life Extension Foundation is currently funding a rodent longevity study testing s-adenosyl-l-methionine (SAMe). Here I beat them to the punch with a cheap and quick fly test. Unfortunately my fly test indicates that SAMe exerts no longevity benefit. In run #181 I tested soy natto because its vitamin K2 content was higher than most foods. Natto turned out to be mildly toxic, and I had been wondering if this negative result could be due to the nattokinase content of natto. Here I find that nattokinase is indeed quite toxic, and thus can explain my earlier negative finding. The surface of the fly food treated with either natto or nattokinase was much wetter than normal, and this also may have had some bearing on the results. Nattokinase is being retested with reduced fly food hydration in run #188. Run #186 Percent Survival on Day supplement 8 14 21 29 37 47 54 64 71 80 90 ___________________________________________________ control one 97 89 83 74 54 29 17 11 6 0 - control two 97 95 80 80 62 44 31 18 13 5 0 colostrum 1/16 tsp 96 86 79 68 43 36 25 14 7 0 - " 1/4 tsp 97 89 72 64 58 25 14 8 0 - - " 1 tsp 94 88 69 47 38 28 16 13 6 0 - nattokinase 36 mg 48 32 29 13 7 7 7 7 0 - - " 144 mg 34 11 11 9 3 3 0 - - - - " 576 mg 46 23 9 5 5 0 - - - - - SAMe 25 mg 95 95 78 65 54 32 16 8 8 3 0 " 100 mg 64 52 46 39 21 9 9 3 0 - - " 400 mg 89 83 68 64 40 23 6 2 0 - - Rate This Message: http://www.cryonet.org/cgi-bin/rate.cgi?msg=26779