X-Message-Number: 27270
Date: Mon, 24 Oct 2005 14:27:34 -0700 (PDT)
From: Doug Skrecky <>
Subject: 201'st update on fly longevity experiments

     This is the 201'st update of my fly longevity experiments. Average
 temperature was 27.6 C during this run. Estimated maximal longevity using
 the formula (363 - T*11.2) is 54 days.
     In (PNAS 99(2): 838-843) a histone acetylation stimulator called
 4-phenybutyrate increased drosophila lifespan at a low dosage. I was
 unable to obtain this product, but did purchase something called Butyrex
 by T.E. Neesby. This billed itself as a calcium/magnesium butyrate.
 Although this proved to be slightly toxic in the current run, the dosages
 tested were all rather high. Run #216 is testing some lower dosages. Note
 that control longevity was also quite poor here.

 Run #201        Percent Survival on Day
 supplement         9 16 22 28 34 40
 ___________________________________
 control one       67 26  4  4  0  -
 control two       81 41 34 19  3  0
 butyrate 75 mg    46 12  8  0  -  -
   "     150 mg    73 27 13  7  0  -
   "     300 mg    53  7  0  -  -  -
   "     600 mg    58 17  8  0  -  -
 histidine 125 mg  55 18 18 18  0  -
   "       500 mg  62  8  0  -  -  -

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