X-Message-Number: 27396
Date: Sun, 27 Nov 2005 19:05:47 -0800 (PST)
From: Doug Skrecky <>
Subject: 205'th update on fly longevity experiments

     This is the 205'th update of my fly longevity experiments. Average
 temperature was 25.8 C during this run. Estimated maximal longevity using
 the formula (363 - T*11.2) is 75 days.
     B.R. donated a small amount of pregnenolone and l-dopa for the
 current run. Pregnenolone was tested with indifferent results in run #1.
 However because of its putative relevance to mammalian aging, I decided
 to do a more detailed test of it here.
     L-dopa offered no benefit. Except at the highest dosage pregnenolone
 exhibited a mild toxicity. Ultra high dosages of pregnenolone are being
 tested in run #223.

 Run #205             Percent Survival on Day
 supplement          6 12 18 24 32 41 51 61 68
 _____________________________________________
 control one        96 86 73 59 36 32 18  5  0
 control two        83 63 63 58 33 13  4  0  -
 pregnenolone 6 mg  83 52 45 38 17 10  0  -  -
   "         13 mg  80 64 56 48 28  8  0  -  -
   "         25 mg  96 78 63 48 19  7  4  4  0
   "         50 mg  96 83 75 63 46 17  4  4  0
 l-dopa 13 mg       94 78 56 44 22  0  -  -  -
   "    25 mg       79 68 57 46 39 25 11  7  0
   "    50 mg       95 70 65 60 45 35 15  0  -
   "   100 mg       81 58 47 39 25 17 11  0  -

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