X-Message-Number: 27681
Date: Tue, 7 Mar 2006 17:24:38 -0800 (PST)
From: Doug Skrecky <>
Subject: coenzyme Q10 is a dud at life extension again

Biochem Mol Biol Int. 1998 Apr;44(4):727-37.
The effects of lifelong ubiquinone Q10 supplementation on the Q9
and Q10 tissue concentrations and life span of male rats and mice.
  The effect of lifelong oral supplementation with ubiquinone Q10
(10 mg/kg/day) was examined in Sprague-Dawley rats and C57/B17
mice. There were no significant differences in survival or
life-span found in either rats or mice. Histopathologic
examination of different rat tissues showed no differences
between the groups. In Q10 supplemented rats, plasma and liver
Q10 levels were 2.6 to 8.4 times higher at all age points than in
control rats. Interestingly, in supplemented rats the Q9 levels
also were significantly higher (p<0.05) in plasma and liver at
ages 18 and 24 months. Neither Q9 nor Q10 levels were affected by
supplementation in kidney, heart, or brain tissues. In spite of
the significant changes in plasma and liver ubiquinone
concentrations, lifelong Q10 supplementation did not prolong or
shorten the lifespan of either rats or mice.

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