X-Message-Number: 27689
Date: Thu, 9 Mar 2006 10:18:37 -0800 (PST)
From: Doug Skrecky <>
Subject: coenzyme Q10 is a dud at life-extension - take 4

[Even with a very short lived mouse strain, coenzyme Q10 still had no
benefit on lifespan.]

Exp Gerontol. 2006 Feb;41(2):130-40. Epub 2006 Jan 4.
Reduced coenzyme Q10 supplementation decelerates senescence in
SAMP1 mice.
  The SAMP1 strain is a mouse model for accelerated senescence
and severe senile amyloidosis. We determined whether
supplementation with coenzyme Q10 (CoQ10) could decelerate aging
in SAMP1 mice and its potential role in aging. Plasma
concentrations of CoQ10 and CoQ9 decreased with age in SAMP1 but
not in SAMR1 mice. Supplementation with reduced CoQ10 (CoQH(2),
250mg/kg/day) for one week increased plasma CoQ10 concentrations,
with an accompanying decrease in plasma CoQ9 concentrations. In
two series of experiments, lifelong supplementation with CoQH(2)
decreased the senescence grading scores from 10 to 14 months,
7 to 15 months, and at 17 months of age. The body weight of female
mice increased from 2 to 10 months of age versus controls in the
second series of experiments. Lifelong CoQH(2) supplementation did
not prolong or shorten the lifespan, nor did it alter the murine
senile amyloid (AApoAII) deposition rate or cancer incidence. In
the second series of experiments, urinary levels of
8-hydroxydeoxyguanosine did not change with age or long-term
supplementation with CoQH(2).Urinary levels of acrolein
(ACR)-lysine adduct increased significantly with age in SAMP1 mice;
however, CoQH(2) had no effect. Thus, lifelong dietary
supplementation with CoQH(2) decreased the degree of senescence
in middle-aged SAMP1 mice.

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