X-Message-Number: 27858
Date: Thu, 20 Apr 2006 10:01:58 -0700 (PDT)
From: Doug Skrecky <>
Subject: rejuvenating arteries in old age

[Decreased endothelial repair has been hypothesised to be largely
responsible for the age-associated progression of atherosclerosis. It may
be possible to upregulate such repair by stimulating the proliferation of
stem cells safely.]

Stem Cells Dev. 2006 Feb;15(1):118-23.
Nutraceuticals synergistically promote proliferation of human stem cells.
  A viable alternative to stem cell transplantation is to design
approaches that stimulate endogenous stem cells to promote healing and
regenerative medicine. Many natural compounds have been shown to promote
healing; however, the effects of these compounds on stem cells have not
been investigated. We report here the effects of several natural compounds
on the proliferation of human bone marrow and human CD34(+) and
CD133(+) cells. A dose-related effect of blueberry, green tea, catechin,
carnosine, and vitamin D(3) was observed on proliferation with human bone
marrow as compared with human granulocyte-macrophage colony-stimulating
factor (hGM-CSF). We further show that combinations of nutrients produce
a synergistic effect to promote proliferation of human hematopoietic
progenitors. This demonstrates that nutrients can act to promote healing
via an interaction with stem cell populations.

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